Relationship between potential opioid-related adverse effects and hospital length of stay in patients receiving opioids after orthopedic surgery

Pharmacotherapy
Laura T PizziEugene Viscusi

Abstract

To determine whether there is an association between opioid-related adverse effects and postoperative hospital length of stay (p-LOS). Retrospective medical record review. Large academic medical center. Random sample of 402 patients (mean age 60.2 yrs, 50.3% female) who underwent orthopedic spine, hip, knee, or shoulder surgery during 2007 and received opioids during or after the procedure. Potential opioid-related adverse effects were identified by using established criteria. Bivariate and multivariate analyses (generalized linear regression model, log transformed) were used to identify predictors of p-LOS. The model also estimated the effect of specific types of adverse effects and adverse-effect combinations on p-LOS. Mean ± SD p-LOS was 3.0 ± 2.1 days; median oral morphine equivalent postoperative dose was 60 mg/day. More than half of the patients (54.2%) experienced one or more adverse effects, 25.6% experienced two or more adverse effects, and 7.2% experienced three or more adverse effects. The composite of nausea and vomiting was experienced by 36.1% of study patients, and 12.6% had at least one emesis episode. Constipation and confusion were documented in 6.5% and 3.7% of patients, respectively. Constipation (p<0.0001),...Continue Reading

References

Sep 1, 1994·Journal of Clinical Anesthesia·M F Watcha, I Smith
Sep 1, 1995·Journal of Clinical Anesthesia·M Ramirez-RuizP F White
Dec 1, 1996·Journal of Clinical Anesthesia·A L KovacF Cox
Dec 10, 1999·Anesthesia and Analgesia·P F White, M F Watcha
Dec 10, 1999·Anesthesia and Analgesia·B L Friedberg
Sep 5, 2002·Journal of Clinical Anesthesia·Beverly K PhilipSteven P Burch
Mar 5, 2003·Journal of Pain and Symptom Management·Gary M OderdaMatthew Samore
Aug 29, 2003·Regional Anesthesia and Pain Medicine·Richard W RosenquistUNKNOWN United States Veterans Administration
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Michelle WheelerArthur G Lipman
Dec 25, 2003·Anesthesia and Analgesia·John J BatesDamian B Murphy
Apr 2, 2004·The American Journal of Hospice & Palliative Care·Robert K SylvesterCaroline Schauer
Jun 30, 2004·Journal of Pain and Symptom Management·Sean Z ZhaoConnie Chen
Jul 20, 2006·Regional Anesthesia and Pain Medicine·James P RathmellEugene R Viscusi
Mar 8, 2007·The Annals of Pharmacotherapy·Gary M OderdaMatthew H Samore
Mar 30, 2007·Clinical Pharmacology and Therapeutics·C E RosowR Israel
May 30, 2008·The New England Journal of Medicine·Jay ThomasRobert J Israel
May 30, 2008·The New England Journal of Medicine·Charles Berde, Samuel Nurko
Sep 5, 2008·The New England Journal of Medicine·Alvaro Sanz Rubiales, María Luisa del Valle Rivero
Sep 23, 2008·Anesthesia and Analgesia·Daewha HongGeraldine Diaz
Aug 29, 2009·Journal of Pain and Symptom Management·Bruce H ChamberlainRobert J Israel

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Citations

Oct 23, 2012·Indian Journal of Anaesthesia·Aloka SamantarayAbha Chandra
Feb 20, 2014·Clinical Orthopaedics and Related Research·Jesse ChrastilThomas F Higgins
Sep 30, 2014·Peptides·Richard J Bodnar
Jan 1, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Timothy J AtkinsonMary Rhorer
Dec 15, 2012·Pharmacotherapy·Sandra L Kane-GillEugene Viscusi
Feb 28, 2014·Pain Practice : the Official Journal of World Institute of Pain·Farid ZandArash Farbood
Mar 17, 2015·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Yuanyuan Liang, Barbara J Turner
Apr 16, 2016·Journal of Shoulder and Elbow Surgery·Carlos A UquillasAndrew S Rokito
Feb 6, 2015·TheScientificWorldJournal·Mihir GuptaKalpna Gupta
Mar 31, 2015·Digestive Diseases and Sciences·Salman NusratMohammad F Madhoun
Oct 29, 2013·Clinical Therapeutics·Timothy J AtkinsonMaira Mirza
Mar 20, 2015·International Journal of Orthopaedic and Trauma Nursing·Kirsten SzötsHanne Konradsen
Mar 5, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Jae Jun LeeJi Su Jang
Nov 12, 2016·The Journal of Arthroplasty·Craig A HansenStephen E Graves
Oct 4, 2016·Postgraduate Medicine·Bruce D Nicholson
Jan 24, 2017·Revista española de anestesiología y reanimación·M Á Gómez-Ríos
Jan 18, 2018·Journal of Pharmacy Practice·Megan E PhillipsStephanie V Phan
Jun 6, 2018·The Cochrane Database of Systematic Reviews·Bridget CandyPatrick Stone
Apr 16, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jayne PawasauskasMichelle Kelley
Nov 7, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Christian ApfelGary M Oderda
Apr 4, 2019·The American Journal of Sports Medicine·Timothy S LerouxAnthony A Romeo
Nov 16, 2019·Journal of General Internal Medicine·Shoshana J HerzigPeter K Lindenauer
Apr 27, 2018·Anesthesiology and Pain Medicine·Jose M SolizKeyuri Popat
May 20, 2020·Clinical Spine Surgery : a Spine Publication·Michael S RohSusan C Peterson
Jul 19, 2017·Journal of Healthcare Risk Management : the Journal of the American Society for Healthcare Risk Management·John J Savarese, Norman G Tabler
Mar 14, 2019·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Harry G GreditzerJean Jose

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