PMID: 9438192Jan 23, 1998Paper

Relationship between protein complotypes and DNA variant haplotypes: complotype-RFLP constellations (CRC)

Human Immunology
S SimonC A Alper

Abstract

From the study of 52 families and 15 homozygous typing cells, 234 MHC complement haplotypes were characterized for features in the DNA of the complotype region: C2/Sst I (2.75, 2.70, 2.65, and 2.40 kb), BF/Taq I (6.6 and 4.5 kb), C4 5'/Bgl II (15 and 4.5 kb), C4 5'/Taq I (7.0, 6.4, 6.0 and 5.4 kb) and C4 3'/Xba I/BamH I (11 and 4 + 7 kb) restriction fragment length polymorphisms (RFLP's), by the presence or absence of C4A, C4B, CYP21A and CYP21B genes and by duplications. Nineteen (of over 1000 theoretically possible) complotype-RFLP constellations (CRC's) were found. The 9 CRC's with two C4 and CYP21 genes were designated A through I. CRC's Bdup and Ddup were like B and D but had duplicated C4B-CYP21B genes. The remaining CRC's had deletions of C4 and/or CYP21 genes and were designated Bdel, Cdel and the like. Individual complement alleles and complotypes were nor randomly distributed among the CRC's. Some complotypes, such as SC01, SC02 and FIC30, were restricted to only 1 CRC; others, such as SC31, FC31, and SC30, were found in several CRC's. Some of the CRC's contained a single complotype, others contained several. Remarkably, there are about 30 CRC-specified complotypes with frequencies of .01 or higher and 14 of .02 or hi...Continue Reading

References

Jan 1, 1976·Transplantation Reviews·M J Hobart, P J Lachmann
Jan 1, 1990·Immunogenetics·C DavrincheA Clerc
Aug 1, 1989·Forensic Science International : Synergy·I SiemensG Pulverer
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M C CarrollT Spies
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P C WhiteJ L Strominger
Jan 1, 1985·Immunogenetics·D R BentleyS J Cross
Jan 1, 1986·Immunogenetics·H L PrenticeJ L Strominger
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I DunhamR D Campbell
Jan 1, 1972·The Journal of Experimental Medicine·C A AlperL Watson
Jul 2, 1973·European Journal of Biochemistry·M Gross-BellardP Chambon
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jan 12, 1984·The New England Journal of Medicine·A S WhiteheadH R Colten
Aug 1, 1984·The Journal of Clinical Investigation·D RaumK H Gabbay
Jan 1, 1982·Human Heredity·Y S Teng, S G Tan
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Z L Awdeh, C A Alper

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Citations

Jan 23, 2002·Immunology Letters·Maria CisłoPiotr Kuśnierczyk
May 16, 2006·Human Immunology·Chester A AlperEdmond J Yunis
Sep 7, 2017·International Journal of Immunogenetics·A E KennedyM T Dorak
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristi L RupertC Yung Yu

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