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Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites

bioRxiv

Sep 19, 2014

Julian EchaveClaus O. Wilke

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Abstract

Evolutionary-rate variation among sites within proteins depends on functional and biophysical properties that constrain protein evolution. It is generally accepted that proteins must be able to fold stably in order to function. However, the relationship between stability constraints and...read more

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Biophysics
Mutant
Guanosine
Site
Structure
Base Sequence
Enzyme Stability
Biological Evolution
17
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  • Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites

    bioRxiv

    Sep 19, 2014

    Julian EchaveClaus O. Wilke

    PMID: 990009423

    DOI: 10.1101/009423

    Abstract

    Evolutionary-rate variation among sites within proteins depends on functional and biophysical properties that constrain protein evolution. It is generally accepted that proteins must be able to fold stably in order to function. However, the relationship between stability constraints and...read more

    Mentioned in this Paper

    Biophysics
    Mutant
    Guanosine
    Site
    Structure
    17

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