PMID: 8946028Nov 4, 1996Paper

Relationship between radiation induced adaptive response in human fibroblasts and changes in chromatin conformation

Mutation Research
Belyaev IYaM Harms-Ringdahl

Abstract

Chromatin conformation changes in the normal human fibroblasts VH-10 were studied by the method of anomalous viscosity time dependence (AVTD). Gamma-irradiation of cells in a dose range of 0.1-3 Gy caused an increase in maximal viscosity of cell lysates. Conversely, irradiation of cells with low doses of 0.5 or 2 cGy resulted in a decrease in the AVTD peaks with a maximum effect approximately 40 min after irradiation. The same exposure conditions were used to study a possible adaptive effect of low doses, measured by changes in cell survival. A primary dose of 2 cGy caused significant modification of cell response to a challenge dose. Approximately 20% protection to challenge doses of 0.5 Gy (p < 0.003), 2 Gy (p < 0.02) and 2.5 Gy (p < 0.002) was observed. However, the direction of this effect (adaptation or synergism) was found to be dependent on a challenge dose. The combined effect of 2 cGy and 1 Gy was significantly synergistic, while no modification was observed for 1.5 Gy and 3 Gy. A partial correlation was found between the AVTD changes and cell survival when the combined effect of a primary dose of 2 cGy and challenge dose was examined. The dose of 2 cGy alone increased survival by 16% (p < 0.0003). These results sugges...Continue Reading

Citations

Nov 21, 1997·Biochimica Et Biophysica Acta· Belyaev IYaM Harms-Ringdahl
Feb 18, 2003·Molecular Biology of the Cell·Marcin R PrzewlokaRobert B Cary
Apr 25, 2008·Radiation Oncology·Silke B SchwarzMoshe Schaffer
Feb 4, 2014·The International Journal of Biochemistry & Cell Biology·Christophe Lavelle, Nicolas Foray
Sep 30, 2004·Radiation and Environmental Biophysics·Moshe SchafferEckhart Dühmke
Feb 20, 2014·Mutation Research. Reviews in Mutation Research· VijayalaxmiMaria Rosaria Scarfi
Jul 8, 2009·Radiation Research·Anna SanninoMaria Rosaria Scarfì
Sep 14, 2001·Radiation Research·I Y BelyaevM Harms-Ringdahl
Jun 20, 2019·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Edouard I Azzam
Dec 12, 2020·Electromagnetic Biology and Medicine·Mahsa MansourianZuhair Mohammad Hassan

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