PMID: 6983356Dec 1, 1982Paper

Relationship between reduced B cell susceptibility to IgM antibodies and reduced IgD-bearing B cells in patients with systemic lupus erythematosus

Arthritis and Rheumatism
H SuzukiH Imura

Abstract

Peripheral blood lymphocytes from 14 patients with systemic lupus erythematosus, 5 patients with rheumatoid arthritis, and 10 normal subjects were cultured for 7 days with or without anti-IgM or anti-IgD antibodies, and IgG- and IgM-secreting cells were assayed by reverse hemolytic plaque assay. Surface immunoglobulin (Ig) isotypes on peripheral blood B cells were also examined by a direct anti-Ig rosetting reaction. In normal subjects and rheumatoid arthritis patients, the spontaneous development of IgG- and IgM-secreting cells was markedly suppressed by anti-IgM or anti-IgD antibodies. Over 50% of peripheral blood B cells were IgD- and IgM-bearing cells in normal subjects and in most patients with rheumatoid arthritis. In lupus patients, however, the suppression of IgG and IgM production by anti-IgM or anti-IgD antibodies was remarkably reduced, especially in the active stage. Furthermore, the percentage of IgD-bearing cells in peripheral blood B cells was remarkably reduced, especially in patients with active disease. There was a good correlation between reduced susceptibility of B cells to anti-IgM antibody-mediated suppression and reduced percentage of IgD-bearing cells in lupus patients.

References

Jan 1, 1977·Immunological Reviews·E S Vitetta, J W Uhr
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P W KincadeR A Good
Mar 1, 1977·European Journal of Immunology·J L Preudhomme
Jan 1, 1978·Arthritis and Rheumatism·A S CohenM Skinner
May 1, 1976·European Journal of Immunology·M FerrariniA Bargellesi
May 1, 1975·Arthritis and Rheumatism·H E Jasin, M Ziff
Jan 1, 1980·Immunological Reviews·M D CooperA R Lawton
Jan 1, 1982·International Archives of Allergy and Applied Immunology·H SuzukiH Imura

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Citations

Jul 2, 2008·Immunologic Research·Stephen H Clarke
Nov 1, 1987·Postgraduate Medical Journal·R J Powell, J S Jenkins

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