Relationship between regional myocardial oxygenation and perfusion in patients with coronary artery disease: insights from cardiovascular magnetic resonance and positron emission tomography

Circulation. Cardiovascular Imaging
Theodoros D KaramitsosJoseph B Selvanayagam

Abstract

It is recognized that the interplay between myocardial ischemia, perfusion, and oxygenation in the setting of coronary artery disease (CAD) is complex and that myocardial oxygenation and perfusion may become dissociated. Blood oxygen level-dependent (BOLD) cardiovascular magnetic resonance (CMR) has the potential to noninvasively measure myocardial oxygenation, whereas positron emission tomography (PET) with oxygen-15 labeled water is the gold standard technique for myocardial blood flow quantification. Thus, we sought to apply BOLD CMR at 3 T and oxygen-15-labeled water PET in patients with CAD and normal volunteers to better understand the relationship between regional myocardial oxygenation and blood flow during vasodilator stress. Twenty-two patients (age, 62+/-8 years; 16 men) with CAD (at least 1 stenosis > or =50% on quantitative coronary angiography) and 10 normal volunteers (age, 58+/-6 years; 6 men) underwent 3-T BOLD CMR and PET. For BOLD CMR, 4 to 6 midventricular short-axis images were acquired at rest and during adenosine stress (140 microg/kg/min). Using PET with oxygen-15-labeled water, myocardial blood flow was measured at baseline and during adenosine in the same slices. BOLD images were divided into 6 segment...Continue Reading

References

Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Mar 1, 1983·Journal of the American College of Cardiology·S ChierchiaA Maseri
Jun 23, 1994·The New England Journal of Medicine·N G UrenP G Camici
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C M WackerL R Schad
Mar 12, 2003·Journal of the American College of Cardiology·Christian M WackerWolfgang R Bauer
Aug 6, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ornella E Rimoldi, Paolo G Camici
Feb 4, 2006·Journal of Magnetic Resonance Imaging : JMRI·Puneet SharmaJohn N Oshinski
May 9, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rohan DharmakumarGraham A Wright
Jun 6, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rohan JagathesanPaolo G Camici
Jan 11, 2007·Radiology·Phillip H KuoShawn E Cowper
Sep 25, 2007·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Theodoros D KaramitsosJane M Francis

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Citations

Jun 4, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Heinrich R Schelbert
Apr 17, 2010·JACC. Cardiovascular Imaging·Matthias G Friedrich
Aug 4, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Chirine ParsaiRaad H Mohiaddin
May 28, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Matthias G Friedrich, Theodoros D Karamitsos
May 2, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Masliza MahmodTheodoros D Karamitsos
Oct 11, 2014·Future Cardiology·Monique BernardFrank Kober
Apr 9, 2011·Current Cardiovascular Imaging Reports·Andrew G Howarth, Matthias G Friedrich
May 14, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Cosima JahnkeIngo Paetsch
Nov 1, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Robert J Gropler
Jul 31, 2010·Expert Review of Cardiovascular Therapy·Charles Cannan, Matthias G Friedrich
Jan 30, 2016·Journal of the American College of Cardiology·Adnan BajwaBijan Modarai
Aug 16, 2011·Journal of Molecular and Cellular Cardiology·Tim P van de HoefMaria Siebes
Nov 21, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Masliza MahmodTheodoros D Karamitsos
Jan 17, 2012·Journal of Magnetic Resonance Imaging : JMRI·Sotirios A TsaftarisRohan Dharmakumar
Jun 15, 2012·Journal of Magnetic Resonance Imaging : JMRI·Florian von Knobelsdorff-Brenkenhoff, Jeanette Schulz-Menger
Jun 2, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nilesh R GhugreGraham A Wright
Jul 3, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Antonella MeloniThoralf Niendorf
Jul 12, 2011·American Heart Journal·Theodoros D KaramitsosStefan Neubauer
Apr 3, 2014·IEEE Transactions on Medical Imaging·Cristian RusuSotirios A Tsaftaris
Apr 9, 2016·JACC. Cardiovascular Imaging·Lauren A BaldassarreUNKNOWN American College of Cardiology’s Cardiovascular Disease in Women Committee
Jul 15, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Susie ParnhamJoseph B Selvanayagam
Jan 21, 2012·Journal of the American College of Cardiology·Andreas SchusterEike Nagel
Mar 19, 2013·Journal of the American College of Cardiology·Theodoros D KaramitsosStefan Neubauer
Oct 23, 2014·European Heart Journal Cardiovascular Imaging·Kady FischerMatthias G Friedrich
Jan 7, 2015·Nature Reviews. Nephrology·Diana Y Y ChiuPhilip A Kalra
Jan 1, 2014·Frontiers in Cardiovascular Medicine·Susie F C ParnhamJoseph B Selvanayagam
May 26, 2012·Journal of the American College of Cardiology·Jayanth R ArnoldJoseph B Selvanayagam
Jan 19, 2013·Journal of the American College of Cardiology·Anthony N DeMariaSotirios Tsimikas
Sep 15, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Giorgos PapanastasiouScott I Semple
Jun 28, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Till HuelnhagenThoralf Niendorf
Feb 15, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Alexander WutzlerWilhelm Haverkamp
Jan 20, 2018·Clinical and Experimental Pharmacology & Physiology·Karthigesh Sree RamanJoseph B Selvanayagam
Jan 21, 2010·Circulation. Cardiovascular Imaging·Dudley J Pennell
Aug 12, 2015·Journal of the American Heart Association·Susie ParnhamJoseph B Selvanayagam
Sep 4, 2015·Circulation. Heart Failure·Sairia DassStefan Neubauer
Feb 11, 2012·Circulation. Cardiovascular Imaging·Theodoros D KaramitsosJoseph B Selvanayagam
Sep 22, 2010·Nature Reviews. Cardiology·Erica Dall'ArmellinaRobin P Choudhury

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