Jan 31, 2020

Relationship Between Risk Factors and Brain Reserve in Late Middle Age: Implications for Cognitive Aging

Frontiers in Aging Neuroscience
Bryan J NethPrashanthi Vemuri


Brain reserve can be defined as the individual variation in the brain structural characteristics that later in life are likely to modulate cognitive performance. Late midlife represents a point in aging where some structural brain imaging changes have become manifest but the effects of cognitive aging are minimal, and thus may represent an ideal opportunity to determine the relationship between risk factors and brain imaging biomarkers of reserve. We aimed to assess neuroimaging measures from multiple modalities to broaden our understanding of brain reserve, and the late midlife risk factors that may make the brain vulnerable to age related cognitive disorders. We examined multimodal [structural and diffusion Magnetic Resonance Imaging (MRI), FDG PET] neuroimaging measures in 50-65 year olds to examine the associations between risk factors (Intellectual/Physical Activity: education-occupation composite, physical, and cognitive-based activity engagement; General Health Factors: presence of cardiovascular and metabolic conditions (CMC), body mass index, hemoglobin A1c, smoking status (ever/never), CAGE Alcohol Questionnaire (>2, yes/no), Beck Depression Inventory score), brain reserve measures [Dynamic: genu corpus callosum fract...Continue Reading

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Mentioned in this Paper

Beck Depression Inventory
Visuospatial Agnosia
Imaging of Brain
Glucose Metabolism
Structure of Genu of Corpus Callosum
Parietal Lobe

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