PMID: 9551877Apr 29, 1998Paper

Relationship between salt and blood pressure in hypertensive patients on chronic ACE-inhibition

Blood Pressure
H HerlitzP Friberg

Abstract

We investigated the effect of a 4-day oral salt load (150 mmol NaCl extra per day) on blood pressure, erythrocyte sodium transport and the activity in the renin-angiotensin system in six males with primary hypertension, who had attained normotension on chronic enalapril treatment for 4 years. The design was a placebo-controlled, randomized, two-way cross over, double-blind study, i.e. each patient served as his own control. Intracellular erythrocyte sodium and potassium content were measured by flame photomometry. The increase in the intracellular sodium concentration during 1 h in 37 degrees C incubation of whole-blood with ouabain (compared with no-ouabain) was measured to determine the rate of active sodium efflux. 24-h blood pressure registration was performed with Space-lab equipment (SL 90202) before and at the end of the salt load. Left ventricular morphology was evaluated with echocardiography and the minimal vascular resistance of the hand vascular bed with water plethysmography at baseline and after 4 years on enalapril. Four years' enalapril treatment caused a significant decrease in blood pressure, left ventricular mass and minimal vascular resistance. During the 4-day salt load average 24-h blood pressure was signi...Continue Reading

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Citations

May 2, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi EndoSadayoshi Ito
Apr 5, 2012·Clinical and Experimental Hypertension : CHE·Sonoko MiyagawaHiroaki Matsubara
Sep 18, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Keiko HosohataAkio Fujimura
Apr 10, 2017·The Cochrane Database of Systematic Reviews·Niels Albert GraudalGesche Jurgens
Dec 23, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Petcharat TrongtorsakLea M D Delbridge
May 2, 2013·The Cochrane Database of Systematic Reviews·Feng J HeGraham A Macgregor
Dec 15, 2020·The Cochrane Database of Systematic Reviews·Niels Albert GraudalGesche Jurgens

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