Relationship between seizure frequency and number of neuronal and non-neuronal cells in the hippocampus throughout the life of rats with epilepsy

Brain Research
Glauber Menezes LopimRicardo Mario Arida

Abstract

The relationship between seizure frequency and cell death has been a subject of controversy. To tackle this issue, we determined the frequency of seizures and the total number of hippocampal cells throughout the life of rats with epilepsy using the pilocarpine model. Seizure frequency varied in animals with epilepsy according to which period of life they were in, with a progressive increase in the number of seizures until 180 days (sixth months) of epileptic life followed by a decrease (330 days-eleventh month) and subsequently stabilization of seizures. Cell counts by means of isotropic fractionation showed a reduction in the number of hippocampal neuronal cells following 30, 90, 180 and 360 days of spontaneous recurrent seizures (SRS) in rats compared to their controls (about 25%-30% of neuronal cell reduction). In addition, animals with 360 days of SRS showed a reduction in the number of neuronal cells when compared with animals with 90 and 180 days of seizures. The total number of hippocampal non-neuronal cells was reduced in rats with epilepsy after 30 days of SRS, but no significant alteration was observed on the 90th, 180th and 360th days. The total number of neuronal cells was negatively correlated with seizure frequenc...Continue Reading

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Citations

Aug 23, 2016·Frontiers in Cellular Neuroscience·Ivan E RepettoAlessandro Vercelli
Jan 8, 2018·Neurosurgical Review·Tim A M Bouwens van der VlisLinda Ackermans
Dec 2, 2020·Life Sciences·Enes AkyuzYam Nath Paudel
May 21, 2020·Brain Research Bulletin·Octávio A C MaiaThiago S Moreira
Jun 1, 2021·Epilepsy & Behavior : E&B·Bruno Raphael Ribeiro CavalcanteRicardo Augusto Leoni De Sousa

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