Relationship between serum 1,25-dihydroxyvitamin D and mortality in patients with pre-dialysis chronic kidney disease

Clinical and Experimental Nephrology
Daijo InagumaKei Kurata

Abstract

It is known that vitamin D has many functions besides involvement in calcium metabolism. It has recently been recognized that vitamin D deficiency is associated with mortality, especially in cardiovascular disease (CVD). Vitamin D deficiency is common in end-stage renal disease, but develops from the early stage of chronic kidney disease (CKD). So we investigated whether the serum level of the activated form of vitamin D (1,25-dihydroxyvitamin D) affected mortality in patients with CKD stages 3 and 4. Between January 1, 1995, and June 30, 2006 we measured serum 1,25-dihydroxyvitamin D In 226 patients with CKD stages 3 and 4 and classified the results into two groups depending on whether the level was below (group I) or above (group II) 20 pg/ml. We ended the follow-up period on December 31, 2006. We compared all-cause and cardiovascular mortality between the two groups. We also examined predictors of mortality by using Cox proportional regression analysis. Two-hundred and twenty-six patients (67 men and 159 women, mean age 67.0) were registered in this study, and groups 1 and 2 comprised 84 and 142 patients, respectively. During the follow-up period 43 patients died. CVD was the major cause of death, followed by infectious dise...Continue Reading

References

Dec 16, 1991·Biochemical and Biophysical Research Communications·M E SandgrenH F DeLuca
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J E BishopA W Norman
Sep 1, 1996·Cell Biology International·T D O'Connell, R U Simpson
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R HausslerP W Jurutka
Jan 14, 2000·Kidney International. Supplement·E SlatopolskyA Dusso
Jun 29, 2002·Journal of the American Academy of Nurse Practitioners·Mary Jo Goolsby
Jul 11, 2002·Histochemistry and Cell Biology·Cristobal FragaRomán Pérez-Fernández
Feb 7, 2003·Journal of the American College of Cardiology·Armin ZittermannPeter Stehle
Aug 2, 2003·The New England Journal of Medicine·Ming TengRavi Thadhani
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tetsuo ShojiYoshiki Nishizawa
Mar 18, 2006·Biomedical Research·Ikuo ImazekiTakashi Nishimura
Aug 22, 2006·Current Medicinal Chemistry·Khanh Vinh Quoc Luong, Lan Thi Hoang Nguyen
Jan 11, 2007·Kidney International·A Remuzzi

❮ Previous
Next ❯

Citations

Feb 25, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Femke BaekeChantal Mathieu
Dec 14, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rukshana ShroffLesley Rees
Oct 29, 2009·Nutrition Research Reviews·Sihe Wang
May 23, 2012·Seminars in Dialysis·Rachel M HoldenCatherine Clase
May 16, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Daniela Veit BarretoZiad A Massy
Dec 18, 2010·Clinical Journal of the American Society of Nephrology : CJASN·William G PetcheyNicole M Isbel
May 28, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Yoshihiro TsujimotoMasaaki Inaba
Sep 18, 2015·Critical Reviews in Clinical Laboratory Sciences·Paul Glendenning, Charles A Inderjeeth
Jan 4, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Eva GravesenKlaus Olgaard
May 28, 2010·Kidney International·Anca Gal-Moscovici, Stuart M Sprague
Jun 10, 2010·Kidney International·Christian F HelvigMartin Petkovich
May 9, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sagar U NigwekarRavi Thadhani
May 25, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jessica KendrickUNKNOWN HOST (Homocysteinemia in Kidney and End Stage Renal Disease) Study Investigators
May 13, 2011·Journal of Renal Care·Georgios AperisPolichronis Alivanis
Apr 23, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Rie ManabeSeiya Okuda
Sep 28, 2010·The American Journal of Medicine·Simerjot K JassalElizabeth Barrett-Connor
Jan 6, 2016·Nephrology·Lihua WangYongning Gao
Apr 22, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Kaoru UmeharaToshiharu Ninomiya
Jan 9, 2018·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Jil B BreidebachRobert Pflugmacher
Aug 28, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Armin ZittermannJochen Börgermann
Oct 28, 2009·Nature Reviews. Nephrology·Carolina R C DoorenbosMartin H de Borst
Dec 6, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Tilman B Drüeke, Eberhard Ritz
Mar 12, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Charles GinsbergIan H de Boer
Sep 5, 2021·BMC Pediatrics·Claudia Suárez-CallejaAdonina Tardón

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.