Relationship between serum and saliva chloramphenicol concentrations.

Antimicrobial Agents and Chemotherapy
J R KoupR L Slaughter

Abstract

The relationship between serum and saliva chloramphenicol (CAP) concentrations was evaluated in 27 paired specimens collected from 20 hospitalized patients during therapy with the drug. A significant (R = 0.80, P < 0.001) but variable relationship was found to exist. Serum protein binding of CAP was also evaluated (43.7 +/- 5.7% bound; N = 24). Differences in CAP binding did not apparently account for a significant portion of the variability in the observed saliva/serum CAP concentration ratios. The degree of variation observed indicated that saliva CAP concentrations could not be relied upon for the prediction of serum CAP concentrations.

References

Jan 1, 1978·Clinical Pharmacokinetics·M Danhof, D D Breimer
Mar 1, 1977·The Journal of Infectious Diseases·S M Finegold
Jan 1, 1978·The Western Journal of Medicine·D K Oxley, C L Fischer
Sep 1, 1978·Antimicrobial Agents and Chemotherapy·J R KoupT R Beam
Dec 1, 1977·The Journal of Allergy and Clinical Immunology·L HendelesR Richardson
Apr 1, 1976·Journal of Pharmacokinetics and Biopharmaceutics·R J Sawchuk, D E Zaske
Dec 1, 1976·American Journal of Diseases of Children·R M BarkinK McIntosh
Dec 1, 1975·Clinical Pharmacology and Therapeutics·C E CookL O'Tuama
Oct 13, 1975·JAMA : the Journal of the American Medical Association·W L ThompsonP S Lietman
Mar 1, 1974·Journal of Dental Research·I D Mandel
Mar 1, 1974·Archives of Disease in Childhood·A W CraftR H Jackson
May 1, 1974·Clinical Pharmacology and Therapeutics·R KoysookoG Levy
Mar 1, 1970·Clinical Pharmacology and Therapeutics·P H LevineJ F Holland
Apr 1, 1953·Journal of Dental Research·I B BENDERS G TASHMAN
Jun 1, 1959·A.M.A. Journal of Diseases of Children·J M SUTHERLAND
Dec 24, 1959·The New England Journal of Medicine·L E BURNSA B CASS
Jun 3, 1965·The New England Journal of Medicine·J L SCOTTJ S LAWRENCE

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.