Relationship between serum calcium and CA 19-9 levels in colorectal cancer

World Journal of Gastroenterology : WJG
Peter FuszekGabor Speer

Abstract

To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients. Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these patients, as well as the relationship between different CaSR genotypes and the data stated above. A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25(OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined. Based on these results, lower levels of serum calcium might be a pathogenic and prognostic factor in colorectal cancer.

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Citations

Apr 19, 2016·Expert Review of Gastroenterology & Hepatology·Jeffrey H LeeWilliam A Ross
Oct 21, 2016·Iranian Journal of Cancer Prevention·Reza DabiriMohammad Reza Zali
Jul 28, 2012·Analytical Chemistry Insights·Susumu TakanoKayo Osawa
Sep 24, 2013·Nutrition and Cancer·Sepehr SalemGholamreza Pourmand
Nov 22, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ying XueKe-Qin Zhang
Aug 3, 2010·International Journal of Colorectal Disease·Paulo FreireCarlos Sofia
Dec 29, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Sadaf Oliai AraghiJessica C Kiefte-de Jong

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