Relationship between serum estrogen concentration and propofol consumption: A prospective observational study of patients undergoing oocyte retrieval

The Journal of Obstetrics and Gynaecology Research
Betul BasaranCavidan Gulerman

Abstract

Controlled ovarian hyperstimulation results in elevated levels of estrogen during in vitro fertilization (IVF). Although serum ovarian steroid hormones were found to influence central nervous system and anesthetic requirements, the relationship between propofol requirements and serum estrogen concentration in women undergoing oocyte retrieval has not been studied. The aim of this study was to determine the relationship between serum estrogen and progesterone concentrations and the required propofol dose for loss of consciousness (LOC). Ninety patients undergoing oocyte retrieval for IVF were enrolled. Anesthesia was induced by administration of 200 mL/h propofol (1%) infusion to reach LOC. Anesthesia was maintained with a propofol infusion guided by entropy. The correlation between estrogen, progesterone levels and propofol dose at the time of LOC was analyzed. Emergence time from anesthesia and total propofol consumption were recorded. The mean serum estradiol concentration was 1825 ±1135 pg/mL. There was a significant positive correlation between serum estradiol and propofol dose required for LOC (Pearson's correlation r = 0.28, P = 0.008). Progesterone had no significant correlation with total propofol dose at the time of LO...Continue Reading

References

Jun 1, 1988·Neuroendocrinology·L H O'ConnorB S McEwen
Jan 1, 1987·Gynecologic and Obstetric Investigation·A BergmanJ Yanai
Sep 1, 1986·The Journal of Clinical Endocrinology and Metabolism·J C VeilleL Speroff
Dec 4, 2003·Psychoneuroendocrinology·Anna H V Söderpalmde Harriet Wit
Apr 21, 2005·Journal of Neurosurgical Anesthesiology·Peggy WheelerHeidi Koenig
Oct 13, 2006·Psychoneuroendocrinology·F van BroekhovenR J Verkes
Jul 29, 2008·Current Opinion in Anaesthesiology·Leo H D J Booij
May 15, 2009·Anesthesia and Analgesia·Nicolas MongardonJean Guglielminotti
Aug 31, 2010·Reproductive Biomedicine Online·Richard Fleming, Julian Jenkins

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