Relationship between serum ferritin and inflammatory biomarkers with insulin resistance in a Persian population with type 2 diabetes and healthy people

International Journal of Food Sciences and Nutrition
Mahkameh AshourpourAhmad Saedisomeolia

Abstract

The correlation between body iron stores and inflammation with insulin resistance in type 2 diabetes is not thoroughly investigated, especially in the Persian population. A cross-sectional study was designed in Tehran, Iran. Fifty-four people with type 2 diabetes and 53 matched healthy participants were included. Serum ferritin, total iron binding capacity, insulin resistance, C-reactive protein and tumor necrosis factor-alpha were measured in both groups. Diabetic patients had higher insulin resistance, hemoglobin A(1)C and serum ferritin. Significant positive correlations were observed between insulin resistance with serum ferritin and tumor necrosis factor-alpha and between serum ferritin and tumor necrosis factor-alpha in diabetic patients. Inter-relationship between insulin resistance, serum ferritin and TNF-alpha was found in type 2 diabetic patients. Serum iron even in the normal range had positive correlation with insulin resistance. It may be because the normal ranges determined for serum ferritin are too wide and the criteria for iron overload are too high.

References

May 15, 1998·Diabetes Care·J M Fernández-RealJ Soler
Jul 30, 2002·Diabetes·José Manuel Fernández-RealWifredo Ricart
Feb 28, 2004·Diabetes Care·Terence T Lao, Lai-Fong Ho
Sep 29, 2004·Diabetes Care·Megan JehnEliseo Guallar
Dec 21, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·C HernándezR Simó
Feb 3, 2006·European Journal of Endocrinology·C E WredeC Hellerbrand
Mar 1, 2006·Diabetes/metabolism Research and Reviews·Ann Van CampenhoutBegoña Manuel-y-Keenoy
Sep 8, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Barbara MlinarMarija Pfeifer
Sep 4, 2007·The Veterinary Journal·Koichi Orino, Kiyotaka Watanabe
Apr 10, 2008·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Faranak SharifiH Jazebi Zadeh
May 9, 2008·Diabetes, Obesity & Metabolism·L JiangD K Yue
Sep 18, 2008·The Journal of Clinical Endocrinology and Metabolism·Liang SunXu Lin
Oct 17, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Mehdi RambodKamyar Kalantar-Zadeh
Nov 1, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Arti ShahMuredach P Reilly

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Citations

Sep 19, 2015·Taiwanese Journal of Obstetrics & Gynecology·Po-Chun KoChun-Sen Hsu
Dec 12, 2013·Diabetes/metabolism Research and Reviews·Ester OrbanCornelia Huth
Apr 25, 2020·Microorganisms·Ana C MoreiraMaria Salomé Gomes

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