Relationship between serum hepatitis B virus DNA and surface antigen with covalently closed circular DNA in HBeAg-negative patients

Journal of Medical Virology
L Y LinH L-Y Chan

Abstract

Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is responsible for viral persistence. This study aimed to investigate the serum surrogate markers for cccDNA and to evaluate the intrahepatic viral events associated with disease activity in HBeAg-negative chronic hepatitis B patients. Thirty-three treatment-naïve patients with a negative HBeAg who had a liver biopsy were studied. Active disease was defined as a serum alanine aminotransferase >40 IU/L and a serum HBV DNA >10,000 copies/ml. This study showed significant correlation between serum HBV DNA and both log cccDNA (r = 0.41, P = 0.018) and log total intrahepatic HBV DNA (r = 0.71, P < 0.0001). No significant correlation was observed between serum HBsAg and log cccDNA (P = 0.15) or log total intrahepatic HBV DNA (P = 0.97). Fourteen and 19 patients had inactive and active disease, respectively. The median log cccDNA and log total intrahepatic HBV DNA (copies/10(6) cells) were significantly higher in patients with active disease compared with those with inactive disease (4.11 vs. 3.53, P = 0.03 and 5.46 vs. 4.64, P < 0.001, respectively). The HBV replicative efficiency, defined as the ratio of serum HBV DNA to cccDNA, was approximately 20% higher in patients ...Continue Reading

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Citations

Jul 12, 2011·The Journal of Infectious Diseases·Henry Lik-Yuen ChanVincent Wai-Sun Wong
Oct 4, 2011·The Journal of Antimicrobial Chemotherapy·James FungMan-Fung Yuen
Feb 23, 2012·Journal of Gastroenterology and Hepatology·Henry Lik-Yuen Chan
Sep 21, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Jeyamani RamachandranPriya Abraham
Jun 4, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Andrzej TarantaKarsten Wursthorn
Feb 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Danny Ka-Ho WongMan-Fung Yuen
Jan 25, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Teresa PollicinoGiovanni Raimondo
Jul 2, 2011·Journal of Hepatology·Henry Lik-Yuen ChanPatrick Marcellin
May 18, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Grace Lai-Hung WongHenry Lik-Yuen Chan
Aug 31, 2016·Journal of Hepatology·Markus CornbergHenry Lik-Yuen Chan
May 24, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Wei-Hua CaoYao Xie
Sep 26, 2014·World Journal of Gastroenterology : WJG·Mohd SuhailIshtiaq Qadri
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Dec 13, 2019·Infectious Agents and Cancer·Wu ShanshanChen Feng
Mar 4, 2021·Viruses·Teresa Pollicino, Giuseppe Caminiti
Apr 1, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Michael BasicKai-Henrik Peiffer

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