Relationship between serum lipid values and atherosclerotic burden in the proximal thoracic aorta.

International Journal of Stroke : Official Journal of the International Stroke Society
Shun KohsakaM R Di Tullio

Abstract

We conducted a cross-sectional analysis in a population-based cohort to compare the strength of the associations among various lipid parameters and the presence of atherosclerotic plaque in the proximal thoracic aorta. As part of Aortic Plaques and Risk of Ischemic Stroke (APRIS) study, 464 subjects were studied (mean age 69.1 +/- 9.0, 251 males and 213 females), including 255 patients with first ischaemic stroke and 209 stroke-free controls. Presence and thickness of atherosclerotic plaque were assessed by transoesophageal echocardiography. Measured lipid parameters included total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, and non-high-density lipoprotein cholesterol, lipoprotein (a), apolipoprotein (Apo) B and A-I levels with their ratio. Overall, atherosclerotic plaque was detected in 326 subjects (70.4%) and 37.6% of these subjects (n=174) had atherosclerotic plaque > or =4 mm. After adjusting for other significant predictors of atherosclerosis, high-density lipoprotein cholesterol level and Apo B/A-I ratio emerged as the strongest predictors of any atherosclerotic plaque (P<0.001 and P=0.004, respectively), followed by individual Apo B (P=0.015) and A-I (P=0.016) levels, triglycerides (P...Continue Reading

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Apr 20, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Enis OzkayaTuncay Kücüközkan
Sep 23, 2014·Tropical Animal Health and Production·Kassahun AsmareEystein Skjerve

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