Relationship between serum prostate specific antigen and the pattern of inflammation in both benign and malignant prostatic disease in Middle Eastern men

International Urology and Nephrology
J T AnimK A Al-Awadi

Abstract

To determine the effect of prostatitis on serum prostate specific antigen in the diagnosis of prostate cancer in Middle Eastern men, H&E-stained sections of all consecutive prostate specimens were reviewed for diagnosis (malignant or benign) and pattern of inflammation. Inflammation was categorized into acute, active chronic and chronic inactive and graded semi-quantitatively according to previously published criteria. Results were correlated with serum PSA obtained from patients' records. Of 513 prostate specimens reviewed; 435 (84.8%) were benign and 78 (15.2%) were malignant. Chronic inactive prostatitis was present in 259 (204 benign, 55 malignant) and active chronic prostatitis in 221 (204 benign, 17 malignant). Acute prostatitis alone was not observed and prostatitis was absent in 33 (27 benign, 6 malignant). There was no significant difference in the prevalence of inactive chronic prostatitis between benign and malignant specimens (p < 0.071), but active chronic prostatitis was more prevalent in benign specimens (p < 0.001). Increasing serum PSA was observed for increasing grades of both inactive and active chronic prostatitis in both benign and malignant disease. Prostate cancer showed higher serum PSA levels than benig...Continue Reading

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Citations

Nov 18, 2006·International Urology and Nephrology·Cuneyt OzdenAli Memis
Dec 13, 2006·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·J T AnimK A Al-Awadi
May 1, 2008·Current Prostate Reports·Jennifer L St Sauver, Steven J Jacobsen
Mar 17, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·O A Mojiminiyi, N A Abdella
Aug 28, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Jimeng HuHaowen Jiang
May 12, 2007·Wiener klinische Wochenschrift·Wolfgang HilbeSabine Zöchbauer-Müller
Dec 16, 2006·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Neva CiftciogluE Olavi Kajander
Jul 21, 2009·Seminars in Cardiothoracic and Vascular Anesthesia·R Clive Landis
Dec 26, 2019·The International Journal of Artificial Organs·Masashi TagayaShunsuke Takahashi
Dec 25, 2007·Wiener medizinische Wochenschrift·Ferdinand Ploner
Jan 1, 2012·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Jiri KubešBuřil Jan
Jun 26, 2020·Experimental and Molecular Pathology·Danilo da Silva LimaFernanda Cristina Alcantara Dos Santos

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