Relationship between serum prostate-specific antigen and prostate volume in Korean men with benign prostatic hyperplasia: a multicentre study

BJU International
Byung Ha ChungDo Hwan Seong

Abstract

To evaluate the relationship between prostate specific antigen (PSA) and prostate volume (PV) in Korean men, as PV is a key predictor of both disease progression and response to medical therapy in patients with benign prostatic hyperplasia (BPH), and PSA has been suggested as a proxy marker to estimate the total PV, mainly in Caucasians. From 1999 to 2004, men aged 50-79 years with lower urinary tract symptoms (LUTS) and BPH were enrolled into this multicentre study. The analyses included 5716 patients presenting to 11 medical centres with LUTS (International Prostate Symptom Score >8, peak urinary flow rate <15 mL/s); they had a mean age of 64.3 years, mean baseline PV of 36.9 mL, and mean baseline PSA level of 2.2 ng/mL. Men with a baseline PSA of >10 ng/mL were excluded, to reduce the likelihood of including occult prostate cancer. A biopsy was taken in those with suspicious findings on a digital rectal examination or serum PSA level of >4 ng/mL, to exclude prostate cancer. Receiver operating characteristic (ROC) curves were constructed to evaluate the ability of serum PSA to predict threshold PV in men with BPH. The PV and serum PSA level had an age-dependent log-linear relationship, the strength of which increased with age...Continue Reading

References

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Citations

Feb 7, 2012·Asian Journal of Andrology·Shu-Jie XiaQi Jiang
May 17, 2014·Asian Journal of Andrology·Giovanni CoronaMario Maggi
Sep 26, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Victor C LinHann-Chorng Kuo
Aug 31, 2010·Urology·Debra J JacobsonSteven J Jacobsen
Jul 14, 2010·The Journal of Urology·Ho-Chun ChoiHyuk-Tae Kwon
Oct 25, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Yong-June KimSang Eun Lee
Jul 5, 2017·International Neurourology Journal·Jung Ki JoHong Sang Moon
Mar 12, 2016·Investigative and Clinical Urology·Jeong Kyun YeoHyung Ji Kim
May 28, 2013·Yonsei Medical Journal·Mun Su ChungByung Ha Chung

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