Relationship between serum urate concentration and clinically evident incident gout: an individual participant data analysis

Annals of the Rheumatic Diseases
Nicola DalbethTony R Merriman

Abstract

To provide estimates of the cumulative incidence of gout according to baseline serum urate. Using individual participant data from four publicly available cohorts (Atherosclerosis Risk in Communities Study, Coronary Artery Risk Development in Young Adults Study, and both the Original and Offspring cohorts of the Framingham Heart Study), the cumulative incidence of clinically evident gout was calculated according to baseline serum urate category. Cox proportional hazards modelling was used to evaluate the relation of baseline urate categories to risk of incident gout. This analysis included 18 889 participants who were gout-free at baseline, with mean (SD) 11.2 (4.2) years and 212 363 total patient-years of follow-up. The cumulative incidence at each time point varied according to baseline serum urate concentrations, with 15-year cumulative incidence (95% CI) ranging from 1.1% (0.9 to 1.4) for <6 mg/dL to 49% (31 to 67) for ≥10 mg/dL. Compared with baseline serum urate <6 mg/dL, the adjusted HR for baseline serum urate 6.0-6.9 mg/dL was 2.7, for 7.0-7.9 mg/dL was 6.6, for 8.0-8.9 mg/dL was 15, for 9.0-9.9 mg/dL was 30, and for ≥10 mg/dL was 64. Serum urate level is a strong non-linear concentration-dependent predictor of inciden...Continue Reading

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Citations

Dec 24, 2018·Current Opinion in Rheumatology·Vicky TaiNicola Dalbeth
Oct 12, 2018·BMJ : British Medical Journal·Lorraine Watson, Edward Roddy
Mar 29, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·J ChenZ-L Sun
Mar 23, 2018·Annals of the Rheumatic Diseases·Xiao Chen, Xiaoqiang Ding
Mar 23, 2018·Annals of the Rheumatic Diseases·Nicola DalbethTony R Merriman
Dec 17, 2019·Current Opinion in Rheumatology·Abhishek Abhishek
Jun 7, 2019·Annals of the Rheumatic Diseases·Pascal RichetteThomas Bardin
Jun 30, 2019·International Journal of Clinical Practice·Emilie TourzelHubert Maisonneuve
Sep 29, 2019·Nature Reviews. Disease Primers·Nicola DalbethLisa K Stamp
Oct 6, 2020·Frontiers in Endocrinology·Juan ChenJiang-Yi Yu
Sep 25, 2020·Scientific Reports·Haibing ChenJun Zhe Min
Jun 21, 2018·Nature Reviews. Rheumatology·Frédéric Lioté, Tristan Pascart
Jun 20, 2020·Nucleosides, Nucleotides & Nucleic Acids·Rosa J Torres
Jun 17, 2020·Nature Reviews. Rheumatology·Mats DehlinEdward Roddy
May 24, 2019·Nature Reviews. Rheumatology·Jie LuWen-Hua Wei
Aug 27, 2018·Clinical Rheumatology·Xiao ChenTaiyi Jin
Oct 30, 2020·Frontiers in Medicine·Irene CalabuigMariano Andrés
Jan 6, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ravi K NarangNicola Dalbeth
Oct 20, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yanyu ChenJianxin Pang
Mar 9, 2021·Seminars in Nephrology·Megan P LeaskTony R Merriman
Apr 3, 2021·Lancet·Nicola DalbethAbhishek Abhishek
Jan 26, 2021·Aging·Chia-Chun TsengShun-Jen Chang
Oct 7, 2018·Joint, Bone, Spine : Revue Du Rhumatisme·Julia GoossensFrédéric Lioté
May 1, 2021·Journal of Clinical Medicine·Paola GalozziPaolo Sfriso
Jan 9, 2022·Journal of Endocrinological Investigation·A SansoneE A Jannini

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