Relationship between site of disease and familial occurrence in Crohn's disease

Digestive Diseases and Sciences
M CottoneA Buccellato

Abstract

Concordance in the extent of disease among the family members of patients with Crohn's disease has not been widely investigated. Furthermore, the relationship between the site of the disease and familial occurrence has never been studied. Our aim was to evaluate the familial occurrence of Crohn's disease in the various sites. Nine hundred thirty-four patients with Crohn's disease, observed consecutively in two gastrointestinal departments, were investigated to determine first-degree familial incidence (in both Crohn's disease and ulcerative colitis). Whenever two or more members were attending the same clinic, only one was regarded as a propositus. The analysis, therefore, was carried out on 882 patients. The exact site of the disease was determined in all patients either at diagnosis or during the follow-up by colonoscopy and by small bowel enema. The rate of concordance in the extent of disease and familial occurrence in the various sites was evaluated and the difference was calculated by chi-square test. Sixty-one propositi were identified among all the patients. Forty-nine had familial occurrence for the same disease (concordant patients), whereas 12 had at least one relative with ulcerative colitis (discordant patients). I...Continue Reading

Citations

Nov 30, 2000·The American Journal of Gastroenterology·C BrignolaG Trallori
Mar 30, 2004·The American Journal of Gastroenterology·Bill NewmanKatherine Siminovitch
Nov 20, 1998·The American Journal of Gastroenterology·A LonardoA Grisendi
Feb 11, 2005·Current Opinion in Gastroenterology·T AhmadDerek Jewell
Aug 5, 2004·Inflammatory Bowel Diseases·Spencer D DornBurton I Korelitz
Apr 28, 2021·Clinical Journal of Gastroenterology·Trilokesh D KidambiSaro Manoukian
Oct 11, 2001·Molecular Genetics and Metabolism·H YangJ I Rotter

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