Relationship between size at birth and hypertension in a genetically homogeneous population of high birth weight

Journal of Hypertension
Ingibjorg GunnarsdottirInga Thorsdottir

Abstract

To investigate the association between birth size and hypertension within a genetically homogeneous population of high birth weight. Cohort-study with retrospectively collected data on size at birth. The study included 4601 men and women born 1914-1935 in Reykjavik, Iceland, who participated in the Reykjavik Study of the Icelandic Heart Association. Birth size measurements, adult blood pressure (BP) and body mass index (BMI), and family history of hypertension. Birth weight was inversely related to hypertension in adulthood in women (P for trend < 0.001). The relationship was of borderline significance in men (P for trend = 0.051). A low ponderal index was significantly associated with high BP in women (P for trend = 0.025) but not men (P > 0.05). For women with an adult BMI > 26 kg/m2, the odds ratio for hypertension for those born weighing < 3.45 kg was 2.1 [95% confidence interval, 1.3-3.3, compared with women born weighing > 3.75 kg. The association was only significant in women without a family history of hypertension. An inverse association between size at birth and adult hypertension was seen in a population of greater birth size than has previously been investigated. The relation was strongest among women born small who...Continue Reading

References

Jun 8, 1991·BMJ : British Medical Journal·N SigfussonG Sigurdsson
Jul 15, 1995·BMJ : British Medical Journal·D J Barker
Apr 1, 1993·British Journal of Obstetrics and Gynaecology·M A WilcoxC E Chilvers
May 1, 1993·European Heart Journal·E SigurdssonN Sigfusson
Jan 7, 1998·Journal of Human Hypertension·H K WolfS Rywik
Jun 9, 1998·Child: Care, Health and Development·E PetridouD Trichopoulos
Aug 29, 1998·Obstetrics and Gynecology·I Thorsdottir, B E Birgisdottir
Mar 11, 2000·American Journal of Human Genetics·A HelgasonK Stefánsson
Mar 31, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·S F OlsenC Gluud
Sep 26, 2000·European Journal of Clinical Nutrition·H Atladottir, I Thorsdottir
Feb 24, 2001·Blood Pressure·D C Felmeden, G Y Lip

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Citations

Jan 20, 2012·Journal of Immigrant and Minority Health·M Margaret Weigel, Maria Elena Caiza Sanchez
Jul 14, 2005·Annual Review of Nutrition·Linda Adair, Darren Dahly
May 17, 2012·Age·Mikaela B von BonsdorffUNKNOWN Age, Gene/Environment Susceptibility-Reykjavik Study Investigators
Mar 14, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·H FujitaT Yamamoto
Jul 15, 2005·Kidney International. Supplement·Valerie A Luyckx, Barry M Brenner
Mar 22, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Anna S OlafsdottirLaufey Steingrimsdottir
Oct 25, 2003·European Journal of Clinical Nutrition·I ThorsdottirG I Palsson
May 18, 2011·Hypertension·Thorhallur Ingi HalldorssonInga Thorsdottir
Feb 24, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E JohannssonT Sveinsson
Mar 13, 2009·Organogenesis·Maarten P KoenersJaap A Joles
Jun 12, 2014·Pediatric Obesity·I W JohnssonJ Gustafsson
Dec 31, 2019·Acta Ophthalmologica·Markus J HaapanenMary Frances Cotch
Mar 23, 2002·Journal of Hypertension·Fiona Broughton Pipkin
Mar 23, 2002·Journal of Hypertension·Klaus O Stumpe
Aug 29, 2007·Revista da Escola de Enfermagem da U S P·Carla Spinella, José Luiz Tatagiba Lamas
Nov 27, 2002·The American Journal of Clinical Nutrition·Ingibjorg GunnarsdottirRafn Benediktsson
Sep 3, 2014·Pediatrics·Majon MullerLenore J Launer

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