PMID: 8592188Nov 1, 1995Paper

Relationship between synaptic activity and prolonged field bursts in the dentate gyrus of the rat hippocampal slice

Journal of Neurophysiology
J S Schweitzer, A Williamson

Abstract

1. Previous studies in the dentate granule cell layer of the rat hippocampal slice have demonstrated that nonsynaptic, seizurelike prolonged field bursts occur in conditions of low extracellular Ca2+ concentration ([Ca2+]o) and elevated [K+]o. We hypothesize that the extracellular ion concentration changes induced by synaptic activation of dentate granule cells would be sufficient to initiate these nonsynaptic bursts. 2. Using ion-selective electrode recording, we observed large changes in [Ca2+]o (from 1.3 mM baseline to approximately 0.7 mM) and [K+]o (from 3.5 to approximately 12 mM) in the dentate granule cell layer during repetitive electrical stimulation of the perforant path in rat hippocampal slices. Concomitant with these changes, bursts of population spikes similar to those seen during spontaneous prolonged field bursts appeared between the individual stimulus-evoked responses in the dentate gyrus in many of the slices studied (19 of 27). 3. Blockade of N-methyl-D-aspartate (NMDA), non-NMDA, and gamma-aminobutyric acid-A (GABAA)-mediated synaptic transmission during perforant path stimulation resulted in a marked reduction of the ion concentration changes and a loss of both stimulus-evoked and stimulus-independent pop...Continue Reading

Citations

Sep 1, 1996·Epilepsia·R D TraubJ G Jefferys
Aug 12, 2000·Journal of Neurophysiology·J S SchweitzerJ L Stringer
Nov 9, 2000·Journal of Neurophysiology·J L HardisonJ V Nadler
Mar 17, 2004·Lasers in Surgery and Medicine·Renata Amadei NicolauJosep Tomàs
Apr 15, 2003·The Journal of Physiology·Andrea BurgoCristina Fasolato
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mahmood Amiry-MoghaddamOle P Ottersen
May 19, 2001·Neurologic Clinics·I NajmD Janigro

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