PMID: 43146Nov 15, 1979

Relationship between the ability of nicotinamide to maintain nicotinamide-adenine dinucleotide in rat liver cell culture and its effect on cytochrome P-450

The Biochemical Journal
A J PaineR F Legg


Rat hepatocytes cultured for 24 h lose 60% of their NAD content. Treatment with nicotinamide prevents the loss of NAD as well as the previously reported loss of cytochrome P-450, suggesting a possible causal relationship. However, isonicotinamide also prevents the loss of cytochrome P-450, but does not increase the concentration of NAD, demonstrating that the ability of nicotinamide to maintain cytochrome P-450 is not apparently related to its effect on the NAD content of cultured hepatocytes.


Mar 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L R ShullJ A Wisniewski
Jun 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C Guguen-GuillouzoA Guillouzo
Aug 1, 1985·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A GuillouzoC Guguen-Guillouzo
Jan 1, 1980·Annals of the New York Academy of Sciences·L F Jaffe
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Apr 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·Y VandenbergheA Guillouzo
Sep 1, 1993·In Vitro Cellular & Developmental Biology. Animal·T MitakaYohichi Mochizuki
Jan 1, 1992·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T MitakaYohichi Mochizuki
Feb 24, 2006·Acta Pharmacologica Sinica·Irena ManovTheodore C Iancu
Sep 1, 1998·Journal of Gastroenterology and Hepatology·T MitakaYohichi Mochizuki
May 13, 1999·International Journal of Experimental Pathology·T Mitaka

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