Relationship between the ABO blood group and COVID-19 susceptibility, severity and mortality in two cohorts of patients.

Blood Transfusion = Trasfusione Del Sangue
Eduardo Muñiz-DiazEnric Contreras

Abstract

Several articles reported the existence of an association between ABO blood groups and COVID-19 susceptibility. Group A and group O individuals showed a higher and lower risk, respectively, of becoming infected. No association was observed between ABO groups and mortality. To verify this association, we performed a retrospective study of two cohorts of patients with different demographic and clinical characteristics. A total of 854 regular blood donors were recruited for convalescent plasma donation after recovering from a mild COVID-19 infection, and a group of 965 patients more severely affected who were transfused during hospitalisation were also included. We also investigated the potential role of the different risk factors on patient outcome and death. To eliminate the confounding effect of risk factors on mortality, a propensity score analysis was performed. Blood group A and blood group O COVID-19 blood donors showed a higher and lower risk, respectively, for acquiring COVID-19. In contrast, this association was not found in the group of patients transfused during hospitalisation, probably due to the great differences in demographic and clinical characteristics between the two groups. Regarding severity, age was one of t...Continue Reading

Citations

Jan 7, 2021·International Journal of Environmental Research and Public Health·Nagla A El-ShitanyShaimaa M Badr-Eldin
Apr 4, 2021·International Journal of Molecular Sciences·Fanny PojeroAnna Aiello
Nov 9, 2021·Frontiers in Immunology·Arvinpreet KaurPrashanth Suravajhala

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