Relationship between the Degrees of Itch and Serum Lipocalin-2 Levels in Patients with Psoriasis

Journal of Immunology Research
Norie AizawaHidemi Nakagawa

Abstract

Lipocalin-2 (LCN2), a protein secreted mainly by activated neutrophils, has been associated with neurodegeneration, obesity, and inflammatory responses. Serum LCN2 concentration has been reported elevated in patients with psoriasis, but lower in patients with atopic dermatitis (AD). Spinal astrocyte-derived LCN2 was found to be involved in enhancement of itch in a mouse model of AD. However, the relationship between LCN2 and itch in patients with psoriasis has not been determined. Objective. This study examined the correlation between serum LCN2 levels and the degrees of itch in patients with psoriasis. Serum LCN2 concentrations were measured by enzyme-linked immunosorbent assays (ELISA) in patients with psoriasis and AD and in healthy controls. The degree of itch was assessed using a visual analog scale (VAS), and disease severity was determined by measuring psoriasis area and severity index (PASI) and scoring atopic dermatitis (SCORAD). Correlations among serum LCN2 level, VAS, PASI, and SCORAD were analyzed statistically. We further examined the serum LCN levels in psoriasis patients before and after biological treatment. Serum LCN2 concentrations were significantly higher in patients with psoriasis and AD than those in heal...Continue Reading

References

Jan 1, 1978·Dermatologica·T Fredriksson, U Pettersson
Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology
Aug 28, 1998·European Journal of Pharmacology·T Andoh, Y Kuraishi
Nov 9, 2000·The British Journal of Dermatology·G YosipovitchC L Goh
Jan 11, 2003·British Journal of Pharmacology·Tsugunobu Andoh, Yasushi Kuraishi
Nov 18, 2003·The British Journal of Dermatology·M NakamuraM Morohashi
Dec 21, 2004·The British Journal of Dermatology·J C SzepietowskiB Wisnicka
Dec 24, 2005·The Journal of Investigative Dermatology·Seong Jun SeoJeung-Hoon Lee
May 31, 2007·The British Journal of Dermatology·S-E ChangJ-H Choi
Feb 22, 2008·Mediators of Inflammation·Adam Reich, Jacek C Szepietowski
Mar 5, 2008·The Journal of Clinical Investigation·Amanda M NelsonDiane M Thiboutot
Apr 22, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·B AmatyaK Nordlind
May 26, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·V CatalánG Frühbeck
Apr 5, 2011·The British Journal of Dermatology·Kenichi TanedaKenji Takamori
Nov 22, 2011·Acta Dermato-venereologica·Adam ReichJacek C Szepietowski
Feb 4, 2012·Clinical and Experimental Dermatology·M KamataS Sato
Jan 21, 2014·Experimental Neurology·Mithilesh Kumar JhaKyoungho Suk
Jul 21, 2015·Nature Medicine·Miho Shiratori-HayashiMakoto Tsuda
Sep 30, 2015·European Journal of Pain : EJP·J C Szepietowski, A Reich
Dec 20, 2015·Journal of Hepatology·Verena WieserHerbert Tilg
Dec 26, 2015·The Journal of Dermatology·Carren S HauShinichi Watanabe
Oct 3, 2017·Life Sciences·Alexandru Florian DeftuVioleta Ristoiu

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Citations

Sep 10, 2020·Journal of Clinical Medicine·Andrzej Kazimierz JaworekMieczysław Pokorski
Oct 28, 2019·Frontiers in Immunology·Chih-Chao ChiangTsong-Long Hwang
Dec 3, 2020·International Journal of Molecular Sciences·Dóra KovácsDániel Törőcsik
Jan 21, 2021·International Journal of Molecular Sciences·Kamila JaworeckaAdam Reich
Nov 14, 2020·International Journal of Molecular Sciences·Eriko KomiyaKenji Takamori
Jun 18, 2021·Hereditas·Huilin WangJiangwei Liu

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