PMID: 8584615Oct 1, 1995Paper

Relationship between the discriminative stimulus effects and plasma concentrations of intramuscular cocaine in rhesus monkeys

Psychopharmacology
X LamasN K Mello

Abstract

The relationship between the discriminative stimulus effects and plasma pharmacokinetics of cocaine was evaluated in six rhesus monkeys trained to discriminate cocaine (0.4 mg/kg, IM) from saline under a FR30 schedule of food presentation. The same monkeys were tested in two procedures. In a cumulative dosing procedure, five cumulative doses of cocaine (0.013-1.3 mg/kg) were administered and discriminative stimulus effects were evaluated 10 min after the administration of each dose. Cocaine plasma concentrations were measured in separate sessions using the same doses and interdose intervals. In a single dosing procedure, the time-courses of the discriminative stimulus effects and plasma concentrations of cocaine were assessed after the administration of cocaine (0.4 mg/kg). A close correspondence between cocaine's discriminative stimulus effects and plasma concentrations was obtained in both procedures. Cocaine was virtually undetectable in plasma at doses that produced saline-appropriate responding (0.013 and 0.04 mg/kg), whereas increasing plasma concentrations were measured at doses that produced primarily cocaine-appropriate responding (0.13 mg/kg or higher). The time-course of the discriminative stimulus effects of cocaine...Continue Reading

References

Jul 1, 1977·Drug and Alcohol Dependence·A L MisraS J Mulé
Jun 1, 1991·Drug and Alcohol Dependence·R W Foltin, M W Fischman
Sep 1, 1989·Canadian Journal of Physiology and Pharmacology·T Inaba
Jun 1, 1989·Pharmacology, Biochemistry, and Behavior·D M Wood, M W Emmett-Oglesby
Jan 1, 1988·Psychopharmacology Series·C R Schuster, C E Johanson
Jul 1, 1988·Clinical Pharmacology and Therapeutics·J J AmbreA J Atkinson
Sep 1, 1985·Clinical Pharmacology and Therapeutics·M J ChowM W Fischman
Jan 1, 1983·Biopharmaceutics & Drug Disposition·J I JavaidJ M Davis
Mar 1, 1981·Journal of Ethnopharmacology·G BarnettR Resnick
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S E LukasJ H Mendelson
Feb 1, 1994·Journal of Clinical Psychopharmacology·S K TeohW Sholar
Apr 1, 1993·Drug and Alcohol Dependence·J BalldinA Sundkler

❮ Previous
Next ❯

Citations

Sep 1, 1996·Drug and Alcohol Dependence·R M Craft, J A Stratmann
Feb 27, 2004·European Journal of Pharmacology·William L Woolverton, Zhixia Wang
Jun 18, 1999·Life Sciences·N SongS C Laizure
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·M B GatchN K Mello
Mar 10, 2009·Pharmacology, Biochemistry, and Behavior·Keith L Shelton, Galina Slavova-Hernandez
Jul 8, 2008·Progress in Neurobiology·Ilana Roth-DeriGal Yadid

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Psychiatric and Mental Health Nursing
R Maughan
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Flavia Valladão ThiesenHelena M T Barros
© 2021 Meta ULC. All rights reserved