Relationship between the diuretic effect of radiocontrast media and their ability to increase renal vascular resistance

The British Journal of Radiology
S K MorcosJ L Haylor

Abstract

The relationship between diuresis and natriuresis induced by radiocontrast media (RCM) and their renal haemodynamic effects were investigated. The effects of the iso-osmolar iotrolan and the hyperosmolar diatrizoate on the renal vascular resistance (RVR) were studied in the filtering and non-filtering variants of the isolated perfused rat kidney (IPRK) preparation. In the non-filtering model, no tubular regulatory process can be activated. The effect of diatrizoate on the RVR of the filtering IPRK in the presence of fursemide (0.3 mmol l-1) an inhibitor of the tubuloglomerular feedback (TGF) was also investigated. There was no significant difference (p > 0.05) in the response of the filtering (n = 6) and non-filtering (n = 6) IPRK to iotrolan. The induced reduction in the renal perfusate flow (RPF) by iotrolan was 20.5 +/- 3.05% and 22.9 +/- 3.03%, respectively. The reduction in the RPF which was observed with diatrizoate in the non-filtering IPRK (n = 5, 17.5 +/- 3.04%) was significantly less (p < 0.05) in comparison to that of the filtering IPRK (n = 6, 26.9 +/- 4.28%). In the frusemide experiments, a reduction in the RPF comparable to that of the non-filtering kidney was observed (n = 5, 13.7 +/- 4.34%). This study demonstra...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S WilcoxH H Schmidt
Nov 1, 1992·The British Journal of Radiology·P BrownA M el Nahas
Jan 1, 1991·Kidney International·I A GoeckeM Alvo
May 1, 1991·The British Journal of Radiology·A A el SayedS K Morcos
Feb 1, 1990·The British Journal of Radiology·M TrewhellaC O'Donnell
Aug 1, 1986·Kidney International·T Maack
Jan 1, 1986·Investigative Radiology·R W KatzbergH W Fischer
Nov 1, 1983·Investigative Radiology·J R ReedR G Luke
Apr 1, 1982·The British Journal of Radiology·R W KatzbergN K Hollenberg
Jan 1, 1995·European Journal of Radiology·S OldroydS K Morcos
Feb 1, 1994·European Journal of Radiology·S OldroydA M el Nahas
Jan 1, 1993·Contributions to Nephrology·P W BrownS K Morcos

Citations

Jul 11, 1998·The British Journal of Radiology·S K Morcos
May 16, 2000·Pharmacotherapy·A T Gerlach, K K Pickworth
Aug 30, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Koji KatoKyoichi Mizuno
Feb 6, 1999·European Journal of Radiology·S K MorcosJ O Karlsson
Apr 3, 1998·Investigative Radiology·W Krause

Related Concepts

Osmovist
Radiographic contrast media
Hypaque
Diuresis
Feedback - System Communication
Salix - substance
Kidney
Osmolality
Triiodobenzoic Acids
Pulmonary Vascular Resistance

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.