PMID: 2105912Feb 1, 1990Paper

Relationship between the inhibition of receptor-induced increase in cytosolic free calcium concentration and the vasodilator effects of nitrates in patients with congestive heart failure

International Journal of Cardiology
E V NegrescuV A Tkachuk

Abstract

Nitroglycerin, isosorbide dinitrate and sodium nitroprusside, like nifedipine, were found to inhibit the receptor-provoked increase of cytosolic free calcium concentration in human platelets loaded with 2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,N',N' - tetraacetate. Sodium nitroprusside and nitroglycerin induced elevation of cyclic guanosine 3',5'-monophosphate content in platelets which correlated with their calcium-blocking activity. Methylene blue and epinephrine decreased the calcium-blocking effect and the influence of nitroglycerin on cyclic guanosine 3'-5'-monophosphate content, but failed to suppress the inhibitory effect of sodium nitroprusside. Ascorbic acid increased the calcium blocking effect of sodium nitroprusside and its influence on cyclic guanosine 3'-5'-monophosphate content, but did not alter the inhibitory effect of nitroglycerin. In order to evaluate the relationship between the mode of action of nitrates at cellular level and their vasodilatory effectiveness, we studied the circulatory response of the forearm to isosorbide dinitrate and the influence of nitroglycerin on free calcium concentration in the platelets in 10 patients with chronic heart failure. We established a signific...Continue Reading

References

Jan 1, 1985·Journal of Cardiovascular Pharmacology·P ErneF R Bühler
Jan 1, 1984·Journal of Cardiovascular Pharmacology·V A Kreye
Apr 1, 1984·International Journal of Cardiology·J A Franciosa
Apr 1, 1980·British Heart Journal·S KlugmannF Camerini

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Citations

Oct 1, 1994·Cardiovascular Drugs and Therapy·K E Torfgård, J Ahlner
Mar 23, 2013·Current Rheumatology Reports·Chieko Mineo
Sep 15, 1993·European Journal of Pharmacology·A A WeberK Schrör
Oct 10, 2002·The American Journal of Cardiology·David C SaneVictor L Serebruany
Oct 26, 2005·Circulation·Jane E Freedman
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J E Freedman, J Loscalzo

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