Relationship between the Montreal Cognitive Assessment and Mini-mental State Examination for assessment of mild cognitive impairment in older adults

BMC Geriatrics
Paula T TrzepaczAlzheimer’s Disease Neuroimaging Initiative

Abstract

The Montreal Cognitive Assessment (MoCA) was developed to enable earlier detection of mild cognitive impairment (MCI) relative to familiar multi-domain tests like the Mini-Mental State Exam (MMSE). Clinicians need to better understand the relationship between MoCA and MMSE scores. For this cross-sectional study, we analyzed 219 healthy control (HC), 299 MCI, and 100 Alzheimer's disease (AD) dementia cases from the Alzheimer's Disease Neuroimaging Initiative (ADNI)-GO/2 database to evaluate MMSE and MoCA score distributions and select MoCA values to capture early and late MCI cases. Stepwise variable selection in logistic regression evaluated relative value of four test domains for separating MCI from HC. Functional Activities Questionnaire (FAQ) was evaluated as a strategy to separate dementia from MCI. Equi-percentile equating produced a translation grid for MoCA against MMSE scores. Receiver Operating Characteristic (ROC) analyses evaluated lower cutoff scores for capturing the most MCI cases. Most dementia cases scored abnormally, while MCI and HC score distributions overlapped on each test. Most MCI cases scored ≥ 17 on MoCA (96.3%) and ≥ 24 on MMSE (98.3%). The ceiling effect (28-30 points) for MCI and HC was less using Mo...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Nov 1, 1992·Journal of Clinical Psychology·T Swirsky-SacchettiC F Gonzalez
Sep 1, 1992·Journal of the American Geriatrics Society·T N Tombaugh, N J McIntyre
May 1, 1982·Journal of Gerontology·R I PfefferS Filos
Apr 14, 1999·Journal of Cardiopulmonary Rehabilitation·D J MoserP L Tilkemeier
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Oct 14, 2008·International Journal of Geriatric Psychiatry·Cheryl A LuisMichael Mullan
Feb 20, 2009·International Journal of Geriatric Psychiatry·Jane A LonieKlaus P Ebmeier
May 11, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 24, 2011·Alzheimer Disease and Associated Disorders·Sandra FreitasIsabel Santana
May 10, 2012·Journal of the American Board of Family Medicine : JABFM·James E GalvinUNKNOWN NINCDS-ADRDA
Jul 6, 2012·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Kriscinda A WhitneySummer L Ibarra
Dec 25, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·David R RoalfSteven E Arnold
Apr 5, 2013·Frontiers in Aging Neuroscience·Shannon L RisacherUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)†
Jan 15, 2014·Biochemical Pharmacology·Bushra ImtiazHilkka Soininen
Mar 1, 2014·Brain : a Journal of Neurology·Hélène AmievaJean-François Dartigues
Mar 1, 2015·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Jed A FalkowskiC Munro Cullum

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Citations

Feb 24, 2016·Alzheimer's Research & Therapy·Kimberly R ChapmanRobert A Stern
May 29, 2016·JMIR Serious Games·Tiffany TongJacques Lee
Jul 13, 2016·International Journal of Cardiology·Quan L HuynhThomas H Marwick
Jul 28, 2016·Journal of the American Medical Directors Association·YanHong DongReshma A Merchant
Jul 16, 2016·The Clinical Neuropsychologist·Erin E RobertsonJoan A O'Keefe
Dec 3, 2016·American Journal of Alzheimer's Disease and Other Dementias·Marina JanelidzeZurab Nadareishvili
Mar 21, 2017·Cerebrovascular Diseases·Sara MazzuccoUNKNOWN Oxford Vascular Study
Mar 16, 2017·Journal of the American Medical Directors Association·Abebaw M YohannesMartin J Connolly
Apr 22, 2017·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Alexandre St-HilaireJoël Macoir
Jun 20, 2017·Journal of Neurologic Physical Therapy : JNPT·Ellen McGoughTeresa Liu-Ambrose
Mar 28, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 25, 2017·Dementia and Geriatric Cognitive Disorders·Stefanie RüdigerUNKNOWN NeuroExercise Study Group
Jul 18, 2017·World Journal of Psychiatry·Felipe José Nascimento BarretoMaila Castro Lourenço Neves
Mar 31, 2018·The Journal of Cardiovascular Nursing·Susan J PresslerMiyeon Jung
May 1, 2018·Dementia and Geriatric Cognitive Disorders Extra·Muath AlkhunizanLoay Basudan
Jul 7, 2018·Journal of Clinical and Experimental Neuropsychology·Samuel L FlanneryLiana Machado
Jan 16, 2018·Alzheimer Disease and Associated Disorders·William DaleMartha K McClintock
Oct 27, 2018·Cutaneous and Ocular Toxicology·Murat GunayBetul Onal Gunay
Dec 1, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O S LevinT N Ostapenko
Sep 8, 2018·The European Respiratory Journal·Katia GagnonNadia Gosselin
Mar 19, 2019·Journal of Geriatric Psychiatry and Neurology·Boaz LevyArdeshir Z Hashmi
Feb 6, 2018·Journal of the International Neuropsychological Society : JINS·Leigh E ColvinStephanie Cosentino
May 31, 2019·Circulation. Heart Failure·Quan L HuynhThomas H Marwick
May 16, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Adam J SantanastoAnne B Newman
Dec 21, 2019·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Wen LiuDandan Song
Aug 15, 2018·Neurology. Clinical Practice·Joyce Gomes-OsmanAlvaro Pascual-Leone
Feb 28, 2020·Clinical Interventions in Aging·Ying Ru FengSean Maher
Dec 15, 2017·Alzheimer Disease and Associated Disorders·Sandra WeintraubJohn C Morris

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Software Mentioned

SAS
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ADNI

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