Relationship between the oestradiol/oocyte ratio and the outcome of assisted reproductive technology cycles with gonadotropin releasing hormone agonist

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Turgut VarLeyla Mollamahmutoglu

Abstract

The aim of this study was to evaluate the relationship of oestradiol level on the day of hCG (peak E2)/oocyte ratio and the outcome of ART cycles. Of the patients who underwent IVF-ET, 600 normal and high responders to the first cycle of COH with gonadotropin releasing hormone (GnRH)-agonist were included in the study. Patients were designated into three groups based on peak E2/oocyte ratio (Group A: <100 pg/ml per oocyte, Group B: 100-200 pg/ml per oocyte, Group C: >200 pg/ml per oocyte). A comparison among groups was made regarding ovarian stimulation characteristics, fertilisation, implantation and pregnancy rates. After the division based on E2/oocyte ratio, in Group C, the number of oocytes retrieved, 2PN and M2 oocyte were statistically lower than both of the other two groups (p = 0.001, 0.001, 0.001, 0.045). HCG day E2 level was significantly different in all groups (p = 0.001), and fertilisation rate was meaningfully highest in Group C and lowest in Group A (p = 0.001). No difference existed among the three groups with respect to the number of embryos transferred and implantation rates. However, clinical pregnancy rate was significantly lower in Group A than others (p = 0.04). In ART cycles suppressed by GnRH-agonist, I...Continue Reading

References

Jan 1, 1995·Human Reproduction·D Ghosh, J Sengupta
Jan 1, 1995·Human Reproduction·D H Edgar
Jan 1, 1995·Human Reproduction·D de Ziegler
Oct 16, 1999·Fertility and Sterility·F I Sharara, H D McClamrock
Aug 9, 2005·Fertility and Sterility·Marco FilicoriBrunilde Roset
Apr 25, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Raoul OrvietoRoy Homburg

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Citations

Sep 23, 2011·Archives of Gynecology and Obstetrics·Özlem MoraloğluEsma Sarikaya
Jan 10, 2012·Journal of Assisted Reproduction and Genetics·Richard W HymanLinda C Giudice
Nov 16, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yudi GengLei Jin

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