PMID: 6112044Apr 6, 1981Paper

Relationship between the presence of dopaminergic neurons and GABA receptors in substantia nigra: effects of lesions

Brain Research
K Gale

Abstract

Submaximal destruction of nigrostriatal dopaminergic projections resulted in a significant (25%) decrease in specific GABA binding in substantia nigra; under these conditions, striatal tyrosine hydroxylase activity was 15-44% of control. In rats with lesions which caused maximal destruction of nigrostriatal dopamine neurons (striatal tyrosine hydroxylase was less than 15% of control), specific GABA binding in substantia nigra was apparently not different from that obtained in intact controls. Two distinct processes may be occurring in response to the destruction of dopamine neurons: (1) the loss of GABA binding sites physically associated with nigral dopamine neurons; and (2) an increase in nigral GABA receptors associated with non-dopaminergic neurons. The latter process may result from a decrease in nigral GABA transmission secondary to the complete loss of dopaminergic synaptic activity in striatum.

References

Apr 1, 1976·The Journal of Pharmacy and Pharmacology·A Dray, D W Straughan
Aug 1, 1976·The Journal of Physiology·A DrayN R Oakley
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G ToffanoE Costa
Feb 15, 1978·European Journal of Pharmacology·J R Walters, J M Lakoski

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Citations

May 25, 1999·Cell·B T Porse, R A Garrett
Apr 1, 1989·FEMS Microbiology Letters·J Fernando FierroJ A Salas
Jun 16, 2018·Annual Review of Microbiology·Nora Vázquez-Laslop, Alexander S Mankin

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