Relationship between the uptake of calcium or phosphorus and alkaline phosphatase activity induced by certain modulators in rat organs

Calcified Tissue International
A NagataY Sakagishi

Abstract

The effects of phorbol ester or calmodulin on the calcium and phosphorus uptakes by rat tissues and their relationship to the alkaline phosphatase activity (ALP) were investigated in vivo. In rat tissues, ALP activity and calcium uptake in the duodenum and liver were clearly induced by phorbol ester treatment, whereas in the calvarium and ileum they were decreased. Phosphorus uptake was increased by the administration of phorbol ester only in the calvarium. In rats pretreated with an injection of indomethacin as an inhibitor of prostaglandin-synthesizing enzyme, the selective uptake of calcium by phorbol ester was eliminated in the duodenum and liver, as was the ALP activity. In contrast, rats showed a marked increase in ALP activity in the ileum after calmodulin treatment. Moreover, the increased uptake of calcium after calmodulin treatment was clearly seen in the ileum, calvarium, and kidney, and an increased uptake in phosphorus was seen in the duodenum, ileum, and calvarium, but not in kidney. Furthermore, prior injection of W-7 or calmidazolium as an antagonist of calmodulin, reduced the increased ALP activities and the uptake of calcium in all organs tested, but did not reduce the increased phosphorus uptake by the calvar...Continue Reading

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Citations

Jan 27, 2007·Journal of Enzyme Inhibition and Medicinal Chemistry·Lucas R M BrunRodolfo C Puche
Aug 2, 2005·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Lei ChenRongqing Zhang
Aug 19, 2015·Journal of Natural Science, Biology, and Medicine·Hameed Fathima, Harish
Jan 8, 2016·Journal of Biomaterials Applications·Sarah T AbdulQaderZuliani Mahmood
Oct 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Z PengH K Väänänen

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