PMID: 9194125Jun 1, 1997Paper

Relationship between time-resolved and non-time-resolved Beer-Lambert law in turbid media

Physics in Medicine and Biology
Y NomuraM Tamura

Abstract

The time-resolved Beer-Lambert law proposed for oxygen monitoring using pulsed light was extended to the non-time-resolved case in a scattered medium such as living tissues with continuous illumination. The time-resolved Beer-Lambert law was valid for the phantom model and living tissues in the visible and near-infrared regions. The absolute concentration and oxygen saturation of haemoglobin in rat brain and thigh muscle could be determined. The temporal profile of rat brain was reproduced by Monte Carlo simulation. When the temporal profiles of rat brain under different oxygenation states were integrated with time, the absorbance difference was linearly related to changes in the absorption coefficient. When the simulated profiles were integrated, there was a linear relationship within the absorption coefficient which was predicted for fractional inspiratory oxygen concentration from 10 to 100% and, in the case beyond the range of the absorption coefficient, the deviation from linearity was slight. We concluded that an optical pathlength which is independent of changes in the absorption coefficient is a good approximation for near-infrared oxygen monitoring.

References

Jan 1, 1992·Advances in Experimental Medicine and Biology·Y Nomura, M Tamura
Nov 1, 1991·Journal of Applied Physiology·A D EdwardsE O Reynolds
Mar 1, 1990·Journal of Applied Physiology·J S WyattE O Reynolds
Jan 1, 1989·Advances in Experimental Medicine and Biology·D T DelpyP van der Zee
Dec 1, 1989·IEEE Transactions on Bio-medical Engineering·S L Jacques
Dec 1, 1989·IEEE Transactions on Bio-medical Engineering·S T FlockM S Patterson
Jan 1, 1989·Advances in Experimental Medicine and Biology·Y NomuraM Tamura
Jan 1, 1987·Advances in Experimental Medicine and Biology·F CartaI Giannini
Dec 1, 1988·Physics in Medicine and Biology·D T DelpyJ Wyatt
Mar 1, 1988·Journal of Biochemistry·A SeiyamaM Tamura
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B ChanceM Young
Jan 1, 1987·Advances in Experimental Medicine and Biology·P Van der Zee, D T Delpy
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Oct 1, 1993·Journal of Applied Physiology·Y Hoshi, M Tamura
Mar 1, 1996·Physics in Medicine and Biology·M OdaM Tamura
Nov 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·K Furutsu, Y Yamada
Nov 1, 1991·Applied Optics·Y HasegawaY Nomura

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Citations

Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M NemotoH Abe
Oct 9, 2009·Medical Physics·Michele ButtiAlessandro Torricelli
Jan 18, 2006·Journal of Biomedical Optics·Chie SatoYoko Hoshi
Jun 12, 2013·NeuroImage·Alessandro TorricelliLorenzo Spinelli
Aug 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Joseph P CulverA G Yodh
Oct 25, 2013·Biomedical Optics Express·M MazurenkaR Macdonald
Sep 15, 2020·Biomedical Optics Express·Heidrun WabnitzAdam Liebert
Jan 11, 2014·Biomedical Optics Express·Lucia ZucchelliLorenzo Spinelli
Jan 22, 1998·Physics in Medicine and Biology·T NakaiM Tamura
May 31, 2014·Biomedical Optics Express·Alexander JelzowRainer Macdonald
Aug 4, 2005·Applied Optics·Johannes SwartlingRinaldo Cubeddu

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