Relationship between tobacco, cagA and vacA i1 virulence factors and bacterial load in patients infected by Helicobacter pylori

PloS One
M SantibáñezG Royo

Abstract

Several biological and epidemiological studies support a relationship between smoking and Helicobacter pylori (H. pylori) to increase the risk of pathology. However, there have been few studies on the potential synergistic association between specific cagA and vacA virulence factors and smoking in patients infected by Helicobacter pylori. We studied the relationship between smoking and cagA, vacA i1 virulence factors and bacterial load in H. pylori infected patients. Biopsies of the gastric corpus and antrum from 155 consecutive patients in whom there was clinical suspicion of infection by H. pylori were processed. In 106 patients H. pylori infection was detected. Molecular methods were used to quantify the number of microorganisms and presence of cagA and vacA i1 genes. A standardized questionnaire was used to obtain patients' clinical data and lifestyle variables, including tobacco and alcohol consumption. Adjusted Odds Ratios (ORadjusted) were estimated by unconditional logistic regression. cagA was significantly associated with active-smoking at endoscope: ORadjusted 4.52. Evidence of association was found for vacA i1 (ORadjusted 3.15). Bacterial load was higher in active-smokers, although these differences did not yield st...Continue Reading

References

Feb 8, 1990·The New England Journal of Medicine·B DrummP M Sherman
Mar 1, 1993·Journal of Clinical Pathology·G M SobalaM F Dixon
Aug 7, 1997·International Journal of Cancer. Journal International Du Cancer·J TrédanielA Hirsch
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·S SuerbaumM Achtman
Feb 13, 1999·Molecular Microbiology·D KersulyteD E Berg
Mar 26, 1999·Gastroenterology·L J Van DoornW G Quint
Aug 17, 1999·Journal of Clinical Microbiology·J C AthertonM J Blaser
Feb 24, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·M JaroszS Ziemlanski
Mar 17, 2001·Scandinavian Journal of Gastroenterology·J H SimánC H Florén
May 26, 2001·The American Journal of Gastroenterology·A RussoL Bertario
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·D FalushS Suerbaum
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Hermann BrennerTil Stümer
Mar 19, 2003·Letters in Applied Microbiology·L CelliniL Marzio
May 10, 2003·The Journal of Biological Chemistry·Darren P LetleyJohn C Atherton
Oct 2, 2003·International Journal of Cancer. Journal International Du Cancer·Carlos A GonzálezElio Riboli
Mar 31, 2004·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ai Machida-MontaniShoichiro Tsugane
Mar 11, 2005·Nature Reviews. Microbiology·Timothy L Cover, Steven R Blanke
Jul 30, 2005·Epidemiology and Infection·M KiviY Tindberg
Aug 6, 2005·Journal of Clinical Microbiology·Shiho YamazakiTakeshi Azuma
Feb 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Bárbara PeleteiroHenrique Barros
Jan 19, 2008·Journal of Medical Microbiology·Richard H ArgentJohn C Atherton
Dec 4, 2009·Journal of Clinical Microbiology·Sungil JangD Scott Merrell
Jan 8, 2010·Journal of Clinical Microbiology·Christine ChungGuillermo Perez-Perez
May 25, 2010·Nature Reviews. Cancer·D Brent Polk, Richard M Peek
Nov 19, 2010·Journal of Clinical Microbiology·Kathleen R JonesJeong-Heon Cha
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lynn KennemannSebastian Suerbaum
Aug 31, 2011·World Journal of Gastroenterology : WJG·Xiao-Qin WangSen-Ke Hu
May 4, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S BeldaG Royo
May 17, 2014·Clinical Medicine Insights. Gastroenterology·Bruna M RoeslerJosé M R Zeitune
Jun 20, 2014·World Journal of Gastroenterology : WJG·Arvind PandeyAlok C Bharti

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Citations

Sep 16, 2015·Helicobacter·Dionyssios N SgourasYoshio Yamaoka
Nov 6, 2015·International Journal of Environmental Health Research·Agostino Di Ciaula
Jun 15, 2016·Toxins·Tran Thi Huyen TrangYoshio Yamaoka
Mar 12, 2017·Folia Microbiologica·Esteban Paredes-OssesApolinaria García Cancino
Feb 26, 2016·World Journal of Gastrointestinal Pathophysiology·Rong-Guang ZhangShuai-Yin Chen
Nov 30, 2018·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Irene LorenzoNuria Aragonés
Oct 3, 2018·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Ana FerroNuno Lunet
Jun 26, 2021·Curēus·Jaskamal PaddaGutteridge Jean-Charles

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Methods Mentioned

BETA
biopsies
PCR
biopsy

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