Relationship between transcranial Doppler-determined pulsatility index and cerebrovascular resistance: an experimental study

Journal of Neurosurgery
M CzosnykaJ D Pickard

Abstract

Clinical studies with transcranial Doppler suggest that the pulsatility of the flow velocity (FV) waveform increases when the distal cerebrovascular resistance (CVR) increases. To clarify this relationship, the authors studied animal models in which the resistance may be decreased in a controlled manner by an increase in arterial CO2 tension, or by a decrease in cerebral perfusion pressure (CPP) in autoregulating animals. Twelve New Zealand white rabbits were anesthetized, paralyzed, and ventilated. Transcranial Doppler basilar artery FV, laser Doppler cortical blood flow, arterial pressure, intracranial pressure, and end-tidal CO2 concentration were measured continuously. Cerebrovascular resistance (CPP divided by laser Doppler cortical flux) and Gosling Pulsatility Index (PI, defined as an FV pulse amplitude divided by a timed average FV) were calculated as time-dependent variables for each animal. Four groups of animals undergoing controlled manipulations of CVR were analyzed. In Group I, arterial CO2 concentration was changed gradually from hypocapnia to hypercapnia. In Group II, gradual hemorrhagic hypotension was used to reduce CPP. In Group III, the short-acting ganglion blocking drug trimetaphan was injected intravenous...Continue Reading

References

Apr 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·M W Quinn, I K Pople
Jun 1, 1992·Journal of Neurosurgery·C A GillerD J Borchers
Jun 1, 1990·Journal of Neurosurgery·C A GillerH H Batjer
Aug 1, 1990·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·J Legarth, C Nolsoe
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·H A Kontos
Oct 1, 1987·American Journal of Obstetrics and Gynecology·L M McCowanK Ritchie
Sep 1, 1986·Journal of Neurosurgery·K F LindegaardH Nornes
Aug 1, 1973·Journal of Neurosurgery·J D MillerT W Langfitt
Sep 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T M MarkwalderR Aaslid
Jan 1, 1994·British Journal of Neurosurgery·M G O'SullivanJ D Miller
Apr 1, 1994·Acta Paediatrica. Supplement·M Hopp
May 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J Hauerberg, M Juhler

❮ Previous
Next ❯

Citations

Jul 3, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J MühlingG Hempelmann
Jul 10, 2001·Surgical Endoscopy·N ErkanI Astarcioglu
Jan 8, 2009·Neurocritical Care·Marek CzosnykaLuzius A Steiner
Mar 8, 2012·Neurocritical Care·Christos Lazaridis, Marek Czosnyka
Oct 6, 1998·Journal of the Autonomic Nervous System·S RoattaM Passatore
Jul 4, 1998·Ultrasound in Medicine & Biology·E Michel, B Zernikow
Oct 12, 2012·Cardiovascular Psychiatry and Neurology·Ioannis HeliopoulosGeorgios Tsivgoulis
May 20, 2005·American Journal of Respiratory and Critical Care Medicine·Ailiang XieDouglas Russell
Mar 13, 2009·Clinical EEG and Neuroscience·Marc L CopersinoDavid A Gorelick
Feb 26, 2011·Fluids and Barriers of the CNS·Mark E WagshulJoseph R Madsen
Aug 16, 2006·Neurosurgical Focus·J A MorenoJ Fernández-Llamazares
Apr 8, 1999·Journal of Neurosurgery·M CzosnykaM Chir
Apr 17, 2001·Journal of Neurosurgery·M Czosnyka
Oct 5, 2013·Neurocritical Care·Georgios V VarsosMarek Czosnyka
Jan 5, 2008·Neurological Research·Marek CzosnykaJohn D Pickard
Jun 20, 2014·BMC Anesthesiology·Charalampos PierrakosDavid De Bels
Feb 9, 2012·Neurocritical Care·Nicolás de RivaMarek Czosnyka
Aug 26, 2006·The Journal of Physiology·Ailiang XieJerome A Dempsey
Jun 12, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·C DubostT Geeraerts
May 5, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Christos LazaridisVibhor Krishna
Mar 10, 2016·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Appavoo ArulvelanKesavapisharady Krishnakumar
Nov 15, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Georgios V VarsosMarek Czosnyka
Oct 14, 2008·Neuro-Chirurgie·T GeeraertsB Vigué
Apr 29, 2008·Parkinsonism & Related Disorders·Shih-Jei TsaiTzer-Bin Lin
Nov 6, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Emmanuel CarreraMarek Czosnyka
Sep 3, 2013·Journal of Clinical Ultrasound : JCU·Teelkien R van VeenMichael A Belfort
Dec 8, 2004·Ultrasound in Medicine & Biology·Hung-Yi HsuHan-Haw Hu
Jun 17, 2004·Neurological Research·Marcelo Galarza, Jorge A Lazareff

❮ Previous
Next ❯

Methods Mentioned

BETA
microsensor

Software Mentioned

Statographic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.