Relationship between treatment effects on progression-free survival and overall survival in multiple myeloma: a systematic review and meta-analysis of published clinical trial data

Oncology Research and Treatment
Shannon CartierCatherine Davis

Abstract

Demonstrating improved overall survival (OS) with new multiple myeloma (MM) treatments is becoming difficult because of extended survival, so progression-free survival (PFS) is commonly used as a surrogate endpoint for OS. We evaluated PFS as a potential surrogate for OS by examining whether observed treatment effects on PFS are positively associated with treatment effects on OS in MM. A systematic literature review identified 21 randomized control trials reporting hazard ratios (HRs) for treatment effects on PFS and OS. Pearson's r estimated the relationship between HRs (HRPFS and HROS), and between log-transformed HRs (log(HRPFS) and log(HROS)). R(2) values were estimated from linear regression models of the HR and the log(HR) relationships. Sensitivity and subgroup analyses examined the robustness of the HR findings. Positive correlations were found between HRPFS and HROS (r = 0.82; p < 0.0001) and between log(HRPFS) and log(HROS) (r = 0.80; p < 0.0001). Linear regression models produced R(2) values of 0.67 and 0.63 when regressing HROS on HRPFS, and log(HROS) on log(HRPFS), respectively. Sensitivity analyses supported the HR findings. This analysis provides evidence for a positive association between treatment effects on PF...Continue Reading

Citations

May 12, 2016·Annals of Hematology·Virginie RondeauXavier Troussard
Jul 11, 2018·International Journal of Technology Assessment in Health Care·Karla Hernandez-VillafuerteNicholas Latimer
Jan 21, 2019·Current Hematologic Malignancy Reports·Sarah A HolsteinPhilip L McCarthy
Mar 19, 2021·American Journal of Hematology·Ghulam Rehman MohyuddinBrian McClune
Jun 16, 2021·Value in Health Regional Issues·Yesenia OrtizEsteban Hernández

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