Relationship between Troponin Elevation, Cardiovascular History and Adverse Events in Patients with acute exacerbation of COPD

COPD
Gianluca CampoMarco Contoli

Abstract

Evidence suggests that troponin (Tn) elevation during acute exacerbation of chronic obstructive pulmonary disease (AECOPD) may predict an increase in mortality risk. We performed an observational study of 935 patients admitted to hospital for AECOPD from January 2010 to December 2012. Principal clinical and laboratory data were recorded, especially ischemic heart disease (IHD) history, Tn T values and cardiovascular drug prescription. The occurrence of all-cause death, cardiac death (CD), nonfatal myocardial infarction (MI), heart failure and cerebrovascular accident (CVA) was assessed on December 2013. Overall, 694 patients respected inclusion and exclusion criteria. We identified 210 (30%) patients without Tn elevation (negative Tn T group) and 484 (70%) patients with Tn elevation (positive Tn T group). With the exception of CVA, all adverse events were significantly higher in positive Tn T group as compared to negative Tn T group. At multivariable analysis, positive Tn T failed to predict all-cause death. Contrarily, positive Tn T emerged as independent predictors of CD (HR 1.61, 95%CI 1.2-2.2, p = 0.04), nonfatal MI (HR 3.12, 95%CI 1.4-8.1, p = 0.03) and composite endpoint including CD and nonfatal MI (HR 1.73, 95%CI 1.2-2....Continue Reading

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Citations

Jan 13, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Arne Didrik HøisethHelge Røsjø
Jan 20, 2016·The Lancet. Respiratory Medicine·Martin I MacDonaldRobert J Hancox
Apr 28, 2017·Nature Reviews. Cardiology·Susanna PriceUNKNOWN Acute Heart Failure Study Group of the European Society of Cardiology Acute Cardiovascular Care Association
Jun 26, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Laurien GoedemansVictoria Delgado
Feb 24, 2021·Heart & Lung : the Journal of Critical Care·Huiying XuMin Sen Yew
Aug 17, 2021·COPD·Anirudh Bakshi, Samy Suissa

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