Feb 8, 2015

Relationship between tumor grade and geometrical complexity in prostate cancer

BioRxiv : the Preprint Server for Biology
José Llanos PérezMaría De Miguel

Abstract

Prostate cancer exhibits high mathematical complexity due to the disruption of tissue architecture. An important part of the diagnostic of prostate tumor samples is the histological evaluation of cellular and glandular organization. The Gleason grade and score, a commonly used prognostic indicator of patient outcome, is based on the match of glandular architectural patterns with standard patterns. Unfortunately, the subjective nature of visual grading leads to variations in scoring by different pathologists. We proposed the fractal dimension of the lumen and the Lempel-Zip complexity of the histopathological patterns as useful descriptors aiding pathologist to standardize histological classification and thus prognosis and therapy planning.

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Mentioned in this Paper

Prostatic Neoplasms
Patterns
Classification
Histology Procedure
Entire Lumen of Body System
Neoplasms
Imaging/Visualization/Scanning
Prostate Carcinoma
Organ
Zipper protein, Drosophila

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