Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study

PloS One
Carlos Fernández-PalomequeFelix Grases

Abstract

Pathological calcification generally consists of the formation of solid deposits of hydroxyapatite (calcium phosphate) in soft tissues. Supersaturation is the thermodynamic driving force for crystallization, so it is believed that higher blood levels of calcium and phosphate increase the risk of cardiovascular calcification. However several factors can promote or inhibit the natural process of pathological calcification. This cross-sectional study evaluated the relationship between physiological levels of urinary phytate and heart valve calcification in a population of elderly out subjects. A population of 188 elderly subjects (mean age: 68 years) was studied. Valve calcification was measured by echocardiography. Phytate determination was performed from a urine sample and data on blood chemistry, end-systolic volume, concomitant diseases, cardiovascular risk factors, medication usage and food were obtained. The study population was classified in three tertiles according to level of urinary phytate: low (<0.610 μM), intermediate (0.61-1.21 μM), and high (>1.21 μM). Subjects with higher levels of urinary phytate had less mitral annulus calcification and were less likely to have diabetes and hypercholesterolemia. In the multivaria...Continue Reading

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Citations

May 8, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ming ChenShi-Ting Li
Dec 12, 2017·Current Opinion in Rheumatology·Ann K Rosenthal
Jun 11, 2020·Journal of Clinical Medicine·Pilar SanchisLuis Masmiquel
Nov 13, 2020·International Journal of Food Sciences and Nutrition·Nicole M Delimont, Sarah Nickel
Jan 5, 2021·Frontiers in Pharmacology·Arsenii ZabirnykJarle Vaage
Apr 10, 2021·Clinical Journal of the American Society of Nephrology : CJASN·David A BushinskyUNKNOWN CaLIPSO Study Group Clinipace GmbH, Intrinsic Imaging, LLC
May 25, 2021·Current Opinion in Nephrology and Hypertension·Smeeta SinhaGlenn M Chertow

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Methods Mentioned

BETA
urine collection

Software Mentioned

SPSS Statistical Package for the Social Sciences

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