PMID: 2118509Sep 1, 1990Paper

Relationship between utilization of proline and proline-containing peptides and growth of Lactococcus lactis

Journal of Bacteriology
E J Smid, W N Konings

Abstract

Proline, which is the most abundant residue in beta-casein, stimulates growth of Lactococcus lactis in a proline-requiring strain (Lactococcus lactis subsp. cremoris Wg2) and in a proline-prototrophic strain (Lactococcus lactis subsp. lactis ML3). Both strains lack a proline-specific uptake system, and free proline can enter the cell only by passive diffusion across the cytoplasmic membrane. On the other hand, lactococci can actively take up proline-containing peptides via the lactococcal di- and tripeptide transport system, and these peptides are the major source of proline. Consequently, lactococcal growth on amino acid-based media is highly stimulated by the addition of proline-containing di- and tripeptides. Growth of L. lactis subsp. lactis ML3 on chemically defined media supplemented with casein does not appear proline limited. Addition of dipeptides (including proline-containing peptides) severely inhibits growth on a casein-containing medium, which indicates that the specific growth rate is determined by the balanced supply of different di- or tripeptides which compete for the same di- and tripeptide transport system.

References

Jan 1, 1989·Critical Reviews in Microbiology·W N KoningsA J Driessen
Jul 15, 1981·Analytical Biochemistry·Y TapuhiB L Karger
Jan 1, 1988·Applied and Environmental Microbiology·A van BovenW N Konings
Feb 1, 1990·Applied and Environmental Microbiology·P S Tan, W N Konings
Jun 1, 1990·Applied and Environmental Microbiology·B W BosmanW N Konings

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Citations

Sep 1, 1993·FEMS Microbiology Reviews·G G Pritchard, T Coolbear
Aug 27, 2013·Applied Microbiology and Biotechnology·Nicolas A L FlahautWillem M de Vos
Feb 1, 1992·FEMS Microbiology Reviews·W N KoningsA J Driessen
Mar 1, 2016·Biotechnology for Biofuels·Jianming LiuChristian Solem
Jul 9, 2004·Cellular Microbiology·Renata R TonelliMaria Júlia M Alves
Jun 9, 2004·Applied and Environmental Microbiology·Carine HuardMarie-Pierre Chapot-Chartier
Mar 27, 1999·Journal of Bacteriology·C DelormeP Renault
Jun 11, 1998·Journal of Bacteriology·R RayaA Chopin
Jan 1, 1992·Applied and Environmental Microbiology·P S TanW N Konings
Nov 23, 1994·Biochimica Et Biophysica Acta·J RuhrmannR Krämer
Sep 1, 1991·Applied and Environmental Microbiology·E J SmidW N Konings
Jul 1, 1993·Journal of Bacteriology·J J GodonP Renault
Jan 1, 1996·Applied and Environmental Microbiology·W MeijerJ Hugenholtz
Dec 1, 1991·Applied and Environmental Microbiology·P S TanW N Konings
Oct 1, 1991·Applied and Environmental Microbiology·J B Jewell, E R Kashket
Dec 29, 2011·Food Microbiology·Quirin Sinz, Wilfried Schwab

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