PMID: 8997565Nov 1, 1996Paper

Relationship between viral genotype and viral load in patients with chronic hepatitis C

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
F GarcíaM C Maroto

Abstract

To determine the distribution of hepatitis C virus (HCV) genotypes and to related genotype to viral load, genotyping and quantification of viral RNA were carried out in 35 patients with chronic hepatitis C. Subtype 1a was most prevalent (43%), followed by subtypes 1b (23%) and 3a (14%). Mean viral load (log HCV-RNA copies/ml) for subtypes 1b, 1a and 3a was 7.1 +/- 1, 5.6 +/- 1.1 and 4.1 +/- 2.4, respectively. The presence of immunoglobulin M was related to the duration of hepatitis and genotype 1 to a more severe hepatic injury and higher viral load. Differences observed in viral load for a single HCV subtype justify the need to quantify HCV-RNA prior to establishing antiviral therapy.

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Citations

Mar 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pablo BarreiroVincent Soriano
Apr 24, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·M M AhmedJ T Wilde
Feb 3, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ashly E JordanDenis Nash

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