Relationship between viral load and behavioral measures of adherence to antiretroviral therapy in children living with human immunodeficiency virus in Latin America

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Horacio A DuarteNISDI PLACES Study Group

Abstract

Few studies have examined antiretroviral therapy adherence in Latin American children. Standardized behavioral measures were applied to a large cohort of human immunodeficiency virus-infected children in Brazil, Mexico, and Peru to assess adherence to prescribed antiretroviral therapy doses during the three days prior to study visits, assess timing of last missed dose, and evaluate the ability of the adherence measures to predict viral suppression. Time trends in adherence were modeled using a generalized estimating equations approach to account for possible correlations in outcomes measured repeatedly in the same participants. Associations of adherence with human immunodeficiency virus viral load were examined using linear regression. Mean enrollment age of the 380 participants was 5 years; 57.6% had undetectable' viral load (<400 copies/mL). At enrollment, 90.8% of participants were perfectly (100%) adherent, compared to 87.6% at the 6-month and 92.0% at the 12-month visit; the proportion with perfect adherence did not differ over time (p=0.1). Perfect adherence was associated with a higher probability of undetectable viral load at the 12-month visit (odds ratio=4.1, 95% confidence interval: 1.8-9.1; p<0.001), but not at enro...Continue Reading

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Citations

Sep 1, 2015·Current Infectious Disease Reports·Olatunji AdetokunbohMojisola Oluwasanu
Jul 30, 2016·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Gabriela RicciCarlos Brites
Jan 27, 2019·Tropical Medicine and Health·Julian NatukundaMasamine Jimba
Sep 10, 2015·Current Opinion in HIV and AIDS·Raziya BobatMelissa Lawler
Aug 30, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Machline P PaganellaUNKNOWN NISDI PLACES Protocol

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