Relationship Between Visceral Obesity and Postoperative Inflammatory Response Following Minimally Invasive Esophagectomy

World Journal of Surgery
Akihiko OkamuraShinji Mine

Abstract

Esophagectomy for esophageal cancer is one of the most invasive surgeries. However, the factors influencing postoperative systemic inflammatory response following esophagectomy have not been elucidated. Recently, visceral fat has been shown to play an important role in both chronic and acute inflammation. In this study, we assessed the relationship between visceral obesity and postoperative inflammatory response following minimally invasive esophagectomy (MIE). Visceral fat area (VFA) was measured using computed tomography in 152 patients undergoing MIE for esophageal cancer. We assessed perioperative serum C-reactive protein (CRP) levels preoperatively and on postoperative days (PODs) 1-5 and analyzed the relationship between VFA and perioperative serum CRP levels. VFA was positively associated with preoperative serum CRP level (P < 0.001). Univariate analysis revealed that VFA was significantly associated with increased serum CRP levels on PODs 1-5 (P < 0.001 for each day), whereas multivariate analysis revealed that it was independently associated with increased serum CRP levels on PODs 1-4 (P = 0.033, 0.035, 0.001, and 0.006, respectively). Similar results were observed in patients who did not have postoperative infectious ...Continue Reading

References

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Oct 27, 2018·Langenbeck's Archives of Surgery·Akihiko OkamuraShinji Mine

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Citations

Sep 1, 2019·Langenbeck's Archives of Surgery·Akihiko OkamuraMasayuki Watanabe
Mar 30, 2021·Frontiers in Oncology·Jessie A Elliott, John V Reynolds
Sep 6, 2021·International Journal of Clinical Practice·Cristian ContiAlfredo Guglielmi
Dec 22, 2019·The Annals of Thoracic Surgery·Mark K FergusonJules Lin
Jan 19, 2022·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Jessie A ElliottJohn V Reynolds

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