PMID: 8466266Mar 1, 1993Paper

Relationship between vitamin K dependent coagulation factors and anticoagulants (protein C and protein S) in neonatal vitamin K deficiency

Archives of Disease in Childhood
T MatsuzakaH Kondoh

Abstract

To determine the relationship between vitamin K dependent coagulation factors and natural anticoagulants, namely protein C and protein S, in various degrees of vitamin K deficiency, plasma values for clotting activity, protein induced by vitamin K absence (PIVKA-II), protein C antigen, gamma-carboxy protein C antigen, and protein S antigen including total and free fractions and activity of protein C were measured in 66 full term and healthy breast fed neonates who did not receive vitamin K supplement at birth. The 66 neonates were divided into a control group (17 cases) and a low group (49 cases) according to their values for clotting activity--that is, > or = 20% or < 20% during the first six days of life--and vitamin K was immediately given when the neonates showed values < 20%. In the low group clotting activity gamma-carboxy protein C, free protein S, and protein C activity was significantly decreased to a minimum on day 2 or 3, and increased in parallel after vitamin K administration. Furthermore, they were positively correlated with one another and inversely cor-correlated with the PIVKA-II concentrations. These findings suggest that simultaneous gamma-carboxylation of coagulation factors and proteins C and S acts to main...Continue Reading

References

Jun 30, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·H TakahashiA Shibata
Jan 1, 1987·Brain & Development·T MatsuzakaY Tsuji
Jan 1, 1986·British Journal of Haematology·M KarpatkinM Nardi
Mar 1, 1985·Acta paediatrica Scandinavica·F SchettiniM M Manzionna
Mar 1, 1985·The Journal of Pediatrics·P A Lane, W E Hathaway
Jul 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J StenfloP Roepstorff
Apr 1, 1971·American Journal of Diseases of Children·W J KeenanH I Glueck
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B Dahlbäck, J Stenflo
Mar 1, 1984·The New England Journal of Medicine·U SeligsohnS I Rapaport
Sep 1, 1984·The Journal of Pediatrics·R H SillsJ R Humbert
Nov 1, 1981·The Journal of Clinical Investigation·J H GriffinC Wideman

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Citations

Aug 31, 1999·The Proceedings of the Nutrition Society·P A Morrissey, P J Sheehy
May 21, 2016·Journal of Neonatal-perinatal Medicine·M TeruyaJ Teruya
Jun 16, 2011·The Journal of International Medical Research·S ZhaoX Zou
May 31, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Ploingarm PetsophonsakulLeon Schurgers

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