Relationship between white matter microstructure abnormalities and ADHD symptomatology in adolescents

Psychiatry Research
Suzanne T Witt, Michael C Stevens

Abstract

The present study sought to evaluate whether white matter microstructure abnormalities observed in a cohort of adolescents with attention-deficit/hyperactivity disorder (ADHD) have specific relationships with either or both Hyperactivity/Impulsivity and Inattentive ADHD symptom domains that would support a dimensional view of ADHD as adopted in the DSM-V. Diffusion tensor imaging (DTI) data were acquired on 22 adolescents diagnosed with ADHD. Multiple regression analyses were performed to determine whether scalar DTI measures in 13 tracts-of-interest demonstrated meaningful associations with Hyperactivity/Impulsivity or Inattentive symptom severity. Fractional anisotropy and radial diffusivity measures of white matter integrity exhibited significant linear relationships with Hyperactivity/Impulsivity and Inattentive symptom severity. However, only radial diffusivity in the right superior longitudinal fasciculus was specifically linked to Inattentive symptom severity and not Hyperactivity/Impulsivity symptom severity. Our results provide preliminary evidence that symptom domains in ADHD are linked to neuroanatomical substrates and confirm the value in examining ADHD from a dimensional perspective.

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Citations

Aug 10, 2015·Neuropsychology Review·Bryon A MuellerJazmin Camchong
Oct 7, 2015·Frontiers in Psychiatry·Adriana Suzart Ungaretti RossiOrlando Francisco Amodeo Bueno
May 1, 2016·Psychiatry Research. Neuroimaging·Eyup Sabri ErcanLuis Augusto Rohde
Jun 8, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Hanneke van EwijkBarbara Franke
Mar 4, 2021·Translational Psychiatry·Kristi R GriffithsMayuresh S Korgaonkar
Apr 16, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chia-Jui TsaiSusan Shur-Fen Gau

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