Relationship of Absolute Telomere Length With Quality of Life, Exacerbations, and Mortality in COPD

Chest
Minhee JinDon D Sin

Abstract

COPD is an age-related disease. The role of cellular senescence in COPD has not been fully elucidated. This study examined the relationship between telomere length of peripheral blood leukocytes and clinical outcomes, including health status, rate of exacerbations, and risk of mortality in individuals with COPD. Using quantitative polymerase chain reaction, we measured the absolute telomere length (aTL) of DNA extracted from blood samples of 576 participants with moderate-to-severe COPD treated with either azithromycin or placebo for 12 months in the Macrolide Azithromycin for Prevention of Exacerbations of COPD (MACRO) study. All participants were followed for approximately 13 months, during which time health status and exacerbations were carefully ascertained, and an additional 29 months for mortality. The rates of exacerbation and mortality were determined by dividing the aTL into two groups using the median value as the cutoff. Participants with shorter telomere length had worse health status defined by higher St. George's Respiratory Questionnaire scores (β = -0.09, P = .034). In the placebo arm of the study, the rate of exacerbation (rate ratio, 1.50; 95% CI, 1.16-1.95; P = .002) and the risk of mortality (hazard ratio, 9...Continue Reading

Citations

Sep 13, 2019·International Journal of Molecular Sciences·Li ZuoTingyang Zhou
Jan 18, 2020·The European Respiratory Journal·Florian B Mayr, Sachin Yende
Feb 21, 2021·Respiratory Research·E Córdoba-LanúsC Casanova
May 28, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·E Haydn WaltersChris Ward
Aug 21, 2021·Respiratory Medicine·Emily S WanMarilyn L Moy
Sep 26, 2021·The European Respiratory Journal·Ana I Hernandez CorderoDon D Sin

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