PMID: 8964654Dec 1, 1995Paper

Relationship of aging and cytokines to the immunomodulation by delta-9-tetrahydrocannabinol on murine lymphoid cells

International Journal of Immunopharmacology
E SnellaH Friedman

Abstract

The effect of delta 9-tetrahydrocannabinol, the major psychoactive component of marijuana, was investigated utilizing lymphoid cells from 2-week, 2-month, and 18-month-old mice. Previous studies have shown a differential modulation by THC related to age such that cells from adult mice could be up-regulated by THC when stimulated by their CD3 receptor. Cells from 2-week-old and 18-month-old mice were resistant to this THC-mediated enhancement. This paper questioned whether these resistant cells could be up-regulated by either addition or removal of cytokines or by exposure to supernatants derived from adult cells. IL-1, IL-4, and IL-6 modified cell proliferation in general, and their effects had some age-related differences, but these actions were independent of THC. In contrast, the THC-induced enhancement appeared to be related in part to IL-2 levels in the adult cell cultures such that when IL-2 was removed, not only did up-regulation not occur, but THC was, in fact, suppressive. Addition of IL-2 or supernatants from adult cells did lead to a modified THC-induced up-regulation of proliferation in cells from adult or 2-week-old mice. Cells from 18-month-old mice remained resistant to this modulation by THC. This did not repres...Continue Reading

References

Jan 1, 1990·International Journal of Immunopharmacology·S H ProssH Friedman
Feb 1, 1974·Science·G G NahasA Morishima
Oct 18, 1994·Biochemical Pharmacology·R MechoulamB R Martin
Nov 1, 1993·Stem Cells·D N ErnstM V Hobbs
May 1, 1993·Mechanisms of Ageing and Development·S ProssH Friedman

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Citations

May 7, 2014·Drug and Alcohol Dependence·Larry KeenWilliam Latimer

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