Relationship of ambulatory blood pressure and the heart rate profile with renal function parameters in hypertensive patients with chronic kidney disease

Clinical and Experimental Hypertension : CHE
Tomohiko KanaokaSatoshi Umemura

Abstract

Strict blood pressure (BP) control is reportedly important for the management of hypertensive patients with chronic kidney disease (CKD). The purpose of this cross-sectional study was to examine whether the variables of ambulatory BP and the heart rate (HR) profile, central hemodynamics, and arterial stiffness were closely related to the renal function parameters (urine albumin excretion rate [UACR] and estimated glomerular filtration rate [eGFR]) observed in 25 consecutive hospitalized hypertensive patients with CKD. There were significant positive relationships between UACR and 24-hour, daytime, and nighttime ambulatory systolic BP. In addition, there were significant negative relationships between UACR and 24-hour and daytime HR variability. The circulating B-type natriuretic peptide level and hemoglobin A1c were also positively related to UACR. With respect to eGFR, although the 24-hour and nighttime HR variability were positively associated with eGFR, the circulating pentosidine and nighttime HR had a negative relationship with eGFR. On the other hand, central hemodynamics and arterial stiffness did not exhibit any significant association with renal function parameters. These results indicate that ambulatory BP and the HR ...Continue Reading

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Citations

Aug 24, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kouichi TamuraSatoshi Umemura
Mar 29, 2018·Experimental Aging Research·Snezana KusljicElizabeth Manias
Sep 5, 2019·Clinical and Experimental Nephrology·Zeynep BiyikSevıl Fısekcı Oktar

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