Relationship of antibiotic resistance phenotype to the R-pyocin susceptibility pattern in clinical isolates of Pseudomonas aeruginosa

Journal of Chemotherapy
L S TzouvelekisN J Legakis

Abstract

One hundred sixteen clinical isolates of Pseudomonas aeruginosa were collected from 7 hospitals in Athens. All strains were studied for their susceptibility to cefotaxime, ceftazidime, carbenicillin, aztreonam, imipenem, nalidixic acid, ciprofloxacin, gentamicin, and chloramphenicol. In addition, the R-pyocin susceptibility pattern was determined and the strains were O-serotyped and tested for their agglutination in acriflavine. The isolates included 53 strains resistant to both gentamicin and carbenicillin, 13 to carbenicillin only, 20 to gentamicin only, and 30 sensitive to gentamicin and carbenicillin. The multiresistant isolates displayed relatively higher resistance to all other antibiotics except aztreonam and cefotaxime. Remarkably 30 out of 53 multiresistant isolates reacted with one pyocin only, namely pyocin R2. This R-pyocin response was not encountered in any other strains of the other antibiotic resistance phenotypes. These isolates belonged to the 0-12 serogroup. The 0-12 serogroup was represented only in a minority of strains giving other R-pyocin reactions. It is interesting that strains reacting with pyocin R5 only were mostly susceptible to antibiotics. The results clearly indicate lipopolysaccharide-core muta...Continue Reading

References

Jul 1, 1979·The Journal of Antimicrobial Chemotherapy·N J LegakisJ Papavassiliou
Jan 1, 1989·Antimicrobial Agents and Chemotherapy·N J LegakisH Kotsifaki
Jun 1, 1987·European Journal of Clinical Microbiology·N J LegakisJ Papavassiliou
Jul 1, 1985·Infection and Immunity·W EngelsC P van Boven
Jan 1, 1984·Annual Review of Microbiology·R E Hancock
May 1, 1984·Infection and Immunity·S J CryzR Germanier
Sep 1, 1984·Reviews of Infectious Diseases·A J Morrison, R P Wenzel
Sep 1, 1982·Journal of Clinical Microbiology·N J LegakisM Papapetropoulou

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Citations

Jul 28, 2018·The Journal of Antimicrobial Chemotherapy·Mar RederoAna I Prieto

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