Relationship of antioxidant and oxidative stress markers in different organs following copper toxicity in a rat model

Toxicology and Applied Pharmacology
Vijay KumarU K Misra

Abstract

Copper (Cu) at a higher level becomes toxic and it can catalyze the formation of highly reactive hydroxyl radical. We report the vulnerability of liver, kidney and brain to different dose of copper sulfate (CuSO4) induced oxidative stress at different time duration. Fifty-four male Wistar rats (weight range=205±10g) were equally divided into three groups. CuSO4 was administered orally to the experimental groups (Group-II and III) up to 90 days in a dose of 100 and 200mg/Kg body weight per day. Saline water was given to the control group (Group-I). At the end of 30, 60 and 90 days of administration, neurobehavioral studies were done and six rats from each group were sacrificed. Their liver, kidney and brain tissues were subjected for Cu, glutathione (GSH), malondialdehyde (MDA) and total antioxidant capacity (TAC) assay. Blood urea nitrogen (BUN), serum creatinine, bilirubin and transaminases were measured. GSH, TAC and MDA levels were correlated with the markers of respective organ dysfunction. Administration of CuSO4 resulted in increased free Cu and MDA level, and decrease GSH and TAC levels in group-II and III compared with group-I. In experimental groups, the reduction in TAC and GSH levels was maximum in liver tissue follo...Continue Reading

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Citations

Oct 30, 2016·Regulatory Toxicology and Pharmacology : RTP·Vijay KumarUsha K Misra
Feb 27, 2018·Nature Reviews. Nephrology·Xin XuFan Fan Hou
Jul 26, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Rupali G ShindeAtanu Barik
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Dec 17, 2019·Journal of Animal Physiology and Animal Nutrition·Yang GaoLianyu Yang
Nov 28, 2019·Journal of Molecular Neuroscience : MN·Jayantee KalitaAbhay Ranjan
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May 26, 2017·Molecular Neurobiology·Jayantee KalitaHimangsu K Bora
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Mar 7, 2021·Diagnostics·Hui-Ju TsaiChao-Hung Kuo
May 5, 2021·Ecotoxicology and Environmental Safety·Na QiaoZhaoxin Tang

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